門脈圧亢進症の発生原因に関する研究--コリン欠乏性肝硬変ラットの肝内微小血管圧および肝循環の血圧勾配について

概要

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In order to determine the localization of an increasing vascular resistance in cirrhosis of the liver, blood pressures in several key points of the hepatic vascular pathway were measured in the normal and choline deficient diet induced liver cirrhosis of the rat. Blood pressures of the intrahepatic terminal portal and central vein were measured by means of the micropuncture technique. The mean blood pressure of the normal rat was; 110mm H2O in the portal vein (liver hilum), 68mm H2O in the terminal portal vein, 28mm H2O in the central vein and 20mm H2O in the inferior vena cava at the hepatic vein orifice. The mean portal vein and the terminal portal vein blood pressure of the choline deficient diet induced cirrhosis rat elevated significantly up to 173mm H2O and to 100mm H2O respectively, but no significant change was detected in the central vein and in the inferior vena cava. These data suggest that an increase in vascular resistance in the cirrhotic liver is present in both the intrahepatic portal vein and the sinusoid, and not in the hepatic venous tree.
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