IgG Deposition in the Lateral Wall of the Endolymphatic Sac in Patients with Menier's Disease

概要

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At the end of this series of reports, further information has substantiated the existence of immunoglobuline (IgG, IgA, IgM) in the lateral wall of endolymphatic sacs, obtained during endolymphatic sac surgery in 20 patients with Meniere's disease and one pair of sacs from a cadavers.<BR>As an immunohistochemical procedure, the PAP method (peroxidase-anti-peroxidase method) was utilized and IgG was recognized in the epithelium and the subepithelial layer of the sacs of 13 of 20 (65%) patients with Meniere's disease, while IgA and IgM were absent in all of the patients. On the other hand, there were no immunoglobulin deposits in the same part of the sac of the cadaver.<BR>Summing up the findings of this series, it can be concluded that there are IgG deposits in the epithelium and the subepithelial layer of the endolymphatic sacs of patients with Meniere's disease, and it is probable that some immunological disorders exist in the endolymphatic space, including the sac, and that they might be closely relataed to one of the causes of endolymphatic hydrops.
日本めまい平衡医学会の論文