Olfactory disturbance caused by Tegafur; Two cases.

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Two patients developed olfactory disturbance after the long-term oral administration of Tegafur as postoperative chemotherapy for cancer. A 53-year-old female received 600mg/day of Tegafur for two years until olfactory disturbance occurred. The second patient was a 54-year-old female who took 200mg/day of Tegafur for two and a half years.A standard olfactory acuity test indicated anosmia in the first and severe hyposmia in the second patient. An intravenous olfaction test showed no response. Slight redness of the mucous membrane of the olfactory cleft was observed through a rigid type endoscope (outer diameter: 1.7 mm). The olfactory disturbance was not relieved by treatment with steroid hormones in the form of nasal drops or the oral administration of Vitamin B.Tegafur, a metabolite of 5-FU compounds, is widely used in the treatment of cancer patients because of its low toxicity and good absorption. Olfactotoxicity of Tegafur should be kept in mind if it is administered for a long time.
耳鼻咽喉科臨床学会の論文