A case of Sweet syndrome treated with low dosis of colchicine.

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A case of Sweet syndrome (acute febrile neutrophilic dermatosis) is reported in a patient with effective treatment by colchicine.In 1964, R. D. Sweet reported eight patients with distinctive and fairly severe illness which refered to acute neutrophilic dermatosis. It is characterized clinically by a various combination of systemic and cutaneous manifestations. The principal features included fever, increased erythrocyte sedimentation rate, polymorphonuclear leukocytosis and raised, tender, erythematous plaques or nodules on the limbs, face and neak. In addition, histological examination shows a dense infiltrate of mature polymorphonuclear leukocytes in the edematous dermis.A dramatic response to systemic corticosteroids is one of the characteristic features of acute febrile neutrophilic dermatosis. In most of the cases, corticosteroids successfully controlled the disease, but a rapid withdrawal of the medication may frequently cause the recurrence.In this article, we report one patient of Sweet syndrome who showed dramatic and rapid response to systemic administration of low dose colchicine.
日本臨床免疫学会の論文