The Repeated Administration of Ketamine Induces an Enhancement of Its Stimulant Action in Mice.
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概要
- 論文の詳細を見る
The modification of the stimulant and motor-incoordinate actions of ketamine induced by repeated administration was investigated by means of ambulatory activity and rota-rod performance in mice, respectively. Ketamine (12.5, 25 and 50 mg/kg, s.c.)increased the mouse''s ambulation in a dosedependent manner, and the repeated 5-times administration at 3 to 4-day intervals enhanced the increment effect. However, a disruption of the rota-rod performance by ketamine was not modified by the repeated treatment. These results suggest that a reverse tolerance to the stimulant action of ketamine is produced, and that a tolerance to its motor-incoordinate action may not cause the enhancement.
- 公益社団法人 日本薬理学会の論文
著者
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Morita Toshihiro
Department Of Anesthesiology And Reanimatology Gunma University School Of Medicine
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Kuribara Hisashi
Division For Behavior Analysis Behavior Research Institute Gunma University School Of Medicine
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Fujita Tatsushi
Department of Anesthesiology and Resuscitology, Gunma University School of Medicine
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Uchihashi Yoshitaka
Division for Behavior Analysis, Behavior Research Institute, Gunma University School of Medicine
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