Effects of YM-09151-2, a potent and selective dopamine D2 antagonist, on the ambulation-increasing effect of methamphetamine in mice.
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概要
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The ambulation-increasing effect of methamphetamine (2 mg/kg, s.c.) was markedly reduced by YM-091 51-2 at 0.01 mg/kg, s.c., in drug-naive mice. The development of reverse tolerance to the ambulation-increasing effect of methamphetamine was also inhibited almost completely when 0.01 mg/kg, s.c., of YM-09151-2 was administered concomitantly in each administration. However, YM-09151-2, at 0.01 mg/kg, was partially suppressed the effect of methamphetamine in mice that exhibited reverse tolerance to methamphetamine.
- 公益社団法人 日本薬理学会の論文
著者
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KURIBARA Hisashi
Division for Behavior Analysis, Behavior Research Institute, Gunma University School of Medicine
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Kuribara Hisashi
Division For Behavior Analysis Behavior Research Institute Gunma University School Of Medicine
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Tadokoro Sakutaro
Division For Behavior Analysis Behavior Research Institute Gunma University School Of Medicine
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