SCH 23390 Equivalently, but YM-09151-2 Differentially Reduces the Stimulant Effects of Methamphetamine, MK-801 and Ketamine: Assessment by Discrete Shuttle Avoidance in Mice.
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概要
- 論文の詳細を見る
The inhibitory actions of the selective dopamine D<SUB>1</SUB> and D<SUB>2</SUB>-antagonists SCH 23390 and YM-09151-2, respectively, on the mouse''s discrete shuttle avoidance were almost equipotent at doses ranging from 0.01-0.1 mg/kg. SCH 23390 reduced the stimulant action of methamphetamine (0.5 mg/kg), MK-801 (0.1 mg/kg) and ketamine (10 mg/kg) with a similar potency. YM-09151-2 also antagonized the actions of these drugs, with the following order of effectiveness: ketamine > MK-801 > methamphetamine. The present results indicate that methamphetamine, MK-801 and ketamine have different characteristics of CNS stimulant action through dopamine D<SUB>2</SUB>-receptors.
- 公益社団法人 日本薬理学会の論文
著者
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Kuribara Hisashi
Division For Behavior Analysis Behavior Research Institute Gunma University School Of Medicine
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Uchihashi Yoshitaka
Division for Behavior Analysis, Behavior Research Institute, Gunma University School of Medicine
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