Breeder differences within Wistar strain rats in step-through type passive avoidance response.
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概要
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Characteristics of acquisition and retention of the one-training and repeated-training passive avoidance responses of the step-through type were investigated in 3 lines of so-called Wistar strain rats: HLA:Wistar, JLA:Wistar and Std: Wistar and in F344/Du Crj rats. In the adaptation and the first acquisition trials in the repeated-training task, Std:Wistar rats took comparatively longer latency times to enter the dark chamber from an illuminated runway than the other lines and strain of rats. In contrast, JLA:Wistar rats took a number of trials to stay for 300 sec or longer in the runway. HLA:Wistar, Std:Wistar and F344/Du Crj rats showed similar response !atencies in the first retention trial. J LA:Wistar rats showed the shortest latencies among 3 lines of Wistar and F334/Du Crj rats, exhibiting much poorer acquisition and retention abilities than the other rats. The response latencies in the retention trials were longer in the order of HLA:Wistar =≥ F344/Du Cri > Std:Wistar > JAL:Wistat rats. These results suggest that there are marked breeder differences in their passive avoidance response even in the rats that have the same strain name.
- 公益社団法人 日本薬理学会の論文
著者
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Kuribara Hisashi
Division For Behavior Analysis Behavior Research Institute Gunma University School Of Medicine
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Tadokoro Sakutaro
Division For Behavior Analysis Behavior Research Institute Gunma University School Of Medicine
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HIRATE Kenji
Division for Behavior Analysis, Behavior Research Institute, Gunma University School of Medicine
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KURIBARA Hisashi
Division for Behavior Analysis, Behavior Research Institute, Gunma University School Medicine
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