DEVELOPMENT OF TOLERANCE TO AMBULATION-INCREASING EFFECT OF SCOPOLAMINE DEPENDENT ON ENVIRONMENTAL FACTORS IN MICE
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概要
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Effects of repeated administration of scopolamine at 0.5, 2.0 and 8.0 mg/kg s.c. on ambulatory activity in mice were investigated. The drug was administered 5 times at intervals of daily, 3-4 days and weekly. The ambulation-increasing effect of scopolamine progressively decreased when the mice were put into a tilting-type round activity cage of 25 cm in diameter and 1 3 cm in height during the presence of the acute drug effect. The tolerance, once produced, was maintained even 1 month after the withdrawal. In contrast, development of tolerance to the ambulation-increasing effect of scopolamine could not be found when the mice were put into a glass jar with a 5.5 cm diameter, in which the ambulation was perfectly restricted, after each drug administration. The present results suggest that the tolerance to the ambulation-increasing effect of scopolamine induced by repeated administration may be elicited by an interaction between the experimental situation and the drug effect.
- 社団法人 日本薬理学会の論文
著者
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KURIBARA Hisashi
Division for Behavior Analysis, Behavior Research Institute, Gunma University School of Medicine
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TADOKORO Sakutaro
Division for Behavior Analysis, Behavior Research Institute, Gunma University School of Medicine
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Kuribara Hisashi
Division For Behavior Analysis Behavior Research Institute Gunma University School Of Medicine
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Tadokoro Sakutaro
Division For Behavior Analysis Behavior Research Institute Gunma University School Of Medicine
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