The anticonflict effect of MK-801, an NMDA antagonist: Investigation by punishment procedure in mice.
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概要
- 論文の詳細を見る
The NMDA antagonist MK-801 at 0.3 mg/kg, i.p. increased the punished response under a MULT VI 1.5/FR 5-punishment schedule of food reinforcement in mice. Furthermore, although neither MK-801 (0.1 mg/kg, i.p.) nor diazepam (0.25 mg/kg, s.c.) was without effect when separately administered, a significant increase in the punished response appeared after the combined administration of these two drugs. The present results suggest that MK-801 not only shows an anticonflict effect, but also enhances the anticonflict effect of benzodiazepine anxiolytics in mice.
- 公益社団法人 日本薬理学会の論文
著者
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Kuribara Hisashi
Division For Behavior Analysis Behavior Research Institute Gunma University School Of Medicine
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Tadokoro Sakutaro
Division For Behavior Analysis Behavior Research Institute Gunma University School Of Medicine
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FUJIWARA Suguru
Division for Behavior Analysis, Behavior Research Institute, Gunma University School of Medicine
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YASUDA Hideko
Division for Behavior Analysis, Behavior Research Institute, Gunma University School of Medicine
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