EFFECT ALTERATION OF METHAMPHETAMINE BY AMINO ACIDS OR THEIR SALTS ON AMBULATORY ACTIVITY IN MICE
スポンサーリンク
概要
- 論文の詳細を見る
Effect alterations of methamphetamine by pretreatment of amino acids or their salts on ambulatory activity in mice were investigated to confirm a fact that certain amino acids, particularly monosodium L-glutamate, are added to methamphetamine by the street users, and that the amino acids augment the effect of methamphetamine. The ambulatory activity of mouse was measured by a tilting-type round activity cage of 25 cm in diameter. The amino acids or their salts tested were monosodium L-glutamate, monosodium L-aspartate, gamma-aminobutyric acid L-alanine, L-lysine hydrochloride and L-arginine hydrochloride. A single administration of each chemical at doses of 1 and 2 g/kg i.p. did not induce a marked change in the ambulatory activity in mice. Methamphetamine 2 mg/kg s.c. induced an increase in the ambulatory activity with a peak at 40 min after the administration, and the increased ambulatory activity persisted for 3 hr. The ambulation-increasing effect of methamphetamine was augmented by the pretreatment of monosodium L-glutamate and monosodium L-aspartate at 30 min before the methamphetamine administration, while attenuated by the pretreatment of L-lysine hydrochloride and L-arginine hydrochloride in a dose-dependent manner. Gamma-aminobutyric acid and L-alanine did not affect the effect of methamphetamine. Similar augmentation and attenuation in the ambulation-increasing effect of methanphetanline were induced by the pretreatment of sodium bicarbonate 0.9g/kg i. p. (urinary alkalizer) and ammonium chloride 0.07 g/kg i.p. (urinary acidifier), respectively. The urinary pH level was elevated by the administration of monosodium L-glutamate, monosodium L-aspartate and sodium bicarbonate, and decreased by L-lysine hydrochloride, L-arginine hydrochloride and ammonium chloride. Gamma aminobutyric acid and L-alanine did not elicit a marked change in the urinary pH level. The present experiment confirms the fact in human that monosodium L-glutamate augments the effect of methamphetamine. Moreover, the present results suggest that monosodium salts of acidic amino acids augment, and conversely monohydrochloric salts of basic amino acids attenuate the effect of methamphetamine. The alterations of the ambulation increasing effect of methamphetamine may be due to the urinary excretion rates of the drug through changes in the urinary pH level after the administration of amino acids or their salts.
- 日本トキシコロジー学会の論文
- 1983-02-25
著者
-
Kuribara Hisashi
Division For Behavior Analysis Behavior Research Institute Gunma University School Of Medicine
-
Tadokoro Sakutaro
Division For Behavior Analysis Behavior Research Institute Gunma University School Of Medicine
関連論文
- BEHAVIORAL EVALUATION OF PSYCHO-PHARMACOLOGICAL AND PSYCHOTOXIC ACTIONS OF METHYLXANTHINES BY AMBULATORY ACTIVITY AND DISCRETE AVOIDANCE IN MICE
- EFFECTS OF STYRENE ON WHEEL-RUNNING AND AMBULATORY ACTIVITIES IN MICE
- CIRCADIAN VARIATION IN SUSCEPTIBILITY TO THE AMBULATION-INCREASING EFFECT OF SCOPOLAMINE IN MICE
- COMPARISON OF SUSCEPTIBILITIES TO THE EFFECTS OF ANTIPSYCHOTIC DRUGS ON LEVER-PRESS AVOIDANCE RESPONSES BETWEEN MICE AND RATS
- AN ANTICONFLICT EFFECT OF GAMMA-1-GLUTAMYLTAURINE (LITORALON) IN RATS
- CHANGES IN METHAMPHETAMINE EFFTCTS ON MOTOR ACTIVITY AFTER PRETREATMENTS WITH AMINO ACIDS AND/OR ITS SALTS IN MICE
- SCHEDULE DEPENDENT CHANGE OF PUNISHED RESPONDING AFTER DIAZEPAM IN RATS
- EFFECT ALTERATION OF METHAMPHETAMINE BY AMINO ACIDS OR THEIR SALTS ON AMBULATORY ACTIVITY IN MICE
- APPLICATION OF FULLY AUTOMATIC MEASUREMENT OF DIURNAL BEHAVIORAL RHYTHMS IN RATS TO PHARMACOTOXICOLOGICAL RESEARCHES (Methodological improvement and its evaluation for toxicity test)
- DEVELOPMENT OF TOLERANCE TO AMBULATION-INCREASING EFFECT OF SCOPOLAMINE DEPENDENT ON ENVIRONMENTAL FACTORS IN MICE
- ENHANCEMENT OF THE BEHAVIORAL TOXICITY INDUCED BY COMBINED ADMINISTRATION OF ETHANOL WITH METHYLXANTHINES : EVALUATION BY DISCRETE AVOIDANCE IN MICE
- STUDY OF ACCUMULATION OF FLUPHENAZINE ENANTHATE AND FLUPHENAZINE DECANOATE, LONG-ACTING NEUROLEPTIC DRUGS, AFTER REPEATED ADMINISTRATIONS BY MEANS OF THEIR INHIBITORY EFFECTS ON THE DISCRIMINATED AVOIDANCE RESPONSE IN RATS
- The anticonflict effect of MK-801, an NMDA antagonist: Investigation by punishment procedure in mice.
- The Repeated Administration of Ketamine Induces an Enhancement of Its Stimulant Action in Mice.
- Cross interaction between methamphetamine and scopolamine by means of ambulatory activity in mice.
- Assessment of the Ambulation-Increasing Effect of Ketamine by Coadministration with Central-Acting Drugs in Mice.
- Comparisons between discrete lever-press and shuttle avoidance responses in mice: Acquisition processes and effects of psychoactive drugs.
- SCH 23390 Equivalently, but YM-09151-2 Differentially Reduces the Stimulant Effects of Methamphetamine, MK-801 and Ketamine: Assessment by Discrete Shuttle Avoidance in Mice.
- Breeder differences within Wistar strain rats in acquisition of discrete shuttle avoidance response and in sensitivity to chlorpromazine.
- Selective suppression of schedule-induced ethanol drinking by antialcoholic drugs in rats.
- Reverse tolerance to ambulation-increasing effects of methamphetamine and morphine in 6 mouse strains.
- Behavioral study on mergocriptine(CBM36-733) by ambulatory activity in mice: Repeated administration and interaction with methamphetamine.
- Enhancement of ambulation-increasing effect of methamphetamine by peripherally-administered 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (R-THBP) in mice.
- Characteristics of effects of repeated scopolamine administration on ambulatory activity in mice and methamphetamine sensitivity in the scopolamine-experimenced mice: Comparison among 6 strains.
- Effects of YM-09151-2, a potent and selective dopamine D2 antagonist, on the ambulation-increasing effect of methamphetamine in mice.
- Differential Antagonism of the Stimulant Effects of MK-801 and Methamphetamine by Ceruletide: Evaluation by Discrete Shuttle Avoidance Response in Mice.
- Behavioral effects of adenosine agonists: Evaluation by punishment, discrete shuttle avoidance and activity tests in mice.
- Characteristics of the Ambulation-Increasing Effect of GBR-12909, a Selective Dopamine Uptake Inhibitor, in Mice.
- Effects of repeated administration of pentazocine on ambulatory activity in mice: Comparison with the effects of morphine and methamphetamine.
- Breeder differences within Wistar strain rats in step-through type passive avoidance response.
- Effects of ceruletide, administered singly and in combination with central-acting drugs, on discrete shuttle avoidance response in mice.
- Effect of OM-853, a Cerebral Metabolic Ameliorator, on Ambulatory Activity and Passive and Active Avoidance Responses in Mice and Mongolian Gerbils.
- A brief brain ischemia produces morphological damage of hippocampal CA1 pyramidal cells without affecting the sensitivities to psychoactive drugs in two types of discrete avoidance tasks in mongolian gerbils.
- Characteristics of the Ambulation-Increasing Effect of the Noncompetitive NMDA Antagonist MK-801 in Mice: Assessment by the Coadministration with Central-Acting Drugs.