Local Antithrombotic Therapy Using a Novel Porous Balloon Catheter.
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概要
- 論文の詳細を見る
The efficacy of local treatment of thrombosis with low-dose antithrombotic drugs (heparin:30 U/kg, or argatroban:0.02 mg/kg) was investigated using a novel porous balloon catheter. This novel balloon catheter can deliver drug into arterial walls without causing vascular trauma. Thrombus formation was significantly inhibited in balloon-injured and locally-treated iliac arteries compared with control balloon-injured arteries in 12 dogs. In the systemic high-dose delivery group (ten times as high as the low dose), thrombus formation in injured arteries was significantly less than that of controls in 7 dogs. Low-dose systemic delivery was not effective at inhibiting this thrombus formation. Thus, local treatment with an antithrombotic drug using this novel porous balloon catheter can prevent thrombosis without influencing systemic coagulability. (Jpn Heart J 2000; 41: 87-95)
- International Heart Journal刊行会の論文
著者
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Morita Toshihiro
Department Of Anesthesiology And Reanimatology Gunma University School Of Medicine
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Nakamura Fumitake
Department Of Chemistry And Biochemistry Suzuka National College Of Technology
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KOBAYAKAWA Naoshi
Department of Cardilogy, Japanese Red Cross Medical Center, Second Department of Internal Medicine, University of Tokyo, Tokyo, Japan.
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UCHIDA Yasumi
Cardilogy Center, Sakura Hospital, Toho University, Chiba, Japan.
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ONITAKE Asako
Department of Cardilogy, Japanese Red Cross Medical Center, Second Department of Internal Medicine, University of Tokyo, Tokyo, Japan.
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TOMARU Takanobu
Department of Cardilogy, Japanese Red Cross Medical Center, University of Tokyo, Tokyo, Japan.
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