鼻腔に初発するmalignant histiocytosisの2剖検例 : 進行性鼻壊疽の1つの病像

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Autopsy findings of the two patients with malignant histiocytosis of the nasal cavity were reported. Clinical findings of them were that of non-healing malignant granuloma of the nasal cavity. The infiltration of atypical histiocytes to various organs was proved in both cases. We believe malignant histiocytosis to be included in the classification of the non-healing granuloma of the nasal cavity.Case 1. A 58-year-old male developed nasal obstruction and puffiness around the left eye. The biopsy specimen from the nasal cavity showed numerous polymorphic cellular infiltration of atypical histiocytes. He was treated with 5030 rads using cobalt-60 and chemotherapy, but the treatment was not effective. He died of bleeding from stomach ulcer 8 months after the onset of the disease. The infiltration of atypical histiocytes was found in the kidney, adrenal glands, skin and liver at autopsy.Case 2. A 41-year-old male had had the feeling of fullness in the ears and headache. Several months later, he developed fever and nasal obstruction. The biopsy specimen from the nasal lesion showed proliferation of histiocytes around and in the wall of arterioles. This finding was simillar to that of angitis. Steroid therapy was not effective and he died of respiratory insufficiency 1 year after the onset of the disease. The infiltration of atypical histiocytes was observed in the lung, liver and spleen at the autopsy.
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