特発性顔面神経麻痺におけるウイルス感染の早期診断に関する研究

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A drawback in the diagnosis of viral infection in Bells palsy is that when the conclusive diagnosis is made, the course of the treatment has already been decided and the diagnosis is thus of little clinical help.In general, at the first viral infection, the antibody which appears earliest is the IgM antibody, normally appearing in the serum two to three days after infection, reaching its maximum several days later and disappearing in the following several weeks. Replacing the IgM antibody, the IgG antibody appears ten or more days after infection and is maintained for se- veral years. Thus, in the event that virus antibodies are found at the initial examination, if it is immediately confirmed that the antibody is the IgM antibody, the early diagnosis of viral infection becomes possible. In order to determine the presence of the IgM antibody to viral infection, a susceptibility test to 2-mercapto-ethanol was employed. An examination was conducted of the sera obtained from 11 cases of Ramsay Hunts syndrome and 22 cases of Bells palsy showing V-Z virus antibody titers of 8-fold and greater. In all the cases of Ramsay Hunts syndrome and 20 cases of Bells palsy, IgM antibody constituted all or the great majority of the antibodies found. In those cases in which antibody titers are revealed at the initial examinaton, it is possible to shorten the time required for the diagnosis of viral infection by using a procedure to prove that the IgM antibody is confirmed.

特発性顔面神経麻痺におけるウイルス感染の早期診断に関する研究

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