The effect of concurrent use of mast-cell stabilizer in the treatment of ulcerative colitis with reference to natural history.

概要

論文の詳細を見る
Ulcerative colitis can be classified into four types (I-IV) by long-term observation of its natural history. In the medical treatment of type. I, which is extremely difficult to control due to frequent severe attacks and steroid dependency, measures should be taken to suppress recurrence. Recently, we attempted to administer to type I patients N-(3', 4'-di-methoxycinnamoyl) anthranilic acid (N-5'), a mast-cell stabilizer. Three out of 4 patients maintained a state of remission for 1.3 to 2.3 years, thus eradicating type I disease. The remaining one patient showed no effect and underwent colectomy. Two patients with disease other than type I, for whom control was difficult although the course was short, N-5' was not effective in one and the effect difficult to determine in the other. However, it seemed that the concurrent use of N-5' was highly likely to eradicate type I, and this was considered worth trying at least once. N-5' may possibly suppress immediate hypersensitivity and also delayed hypersensitivity.
日本大腸肛門病学会の論文