2.Histopathological Studies on Intestinal Behçet's Disease

概要

論文の詳細を見る
Six cases of intestinal Behçet's disease were studied histopathologically. The intestinal changes were mostly seen at the ileo-coecal portion and were characterized by the formation of a definite undermined ulcer extending to the proper muscle layer. Proliferation of the marginal epithelium was so prominent that it often hung down on the ulcer basis. Simultaneously it was noted that a fissuring occurred either tangentially or transversly to the ulcer basis. The former caused a perforation while the latter resulted in the formation of an intramural fistula.<BR>It was found that the basic pathologic process in intestinal Behçet's disease was first manifested as venulitis with mononuclear cell infiltration. The change was then extended to much larger veins, resulting in their obliteration. Based upon these vascular changes, ulcers and fissurings were produced.<BR>It was also revealed that various changes taking place in other organs in Behçet's disease were principally caused by similar venulitis and phlebitis.
日本大腸肛門病学会の論文