亜急性および慢性日本脳炎の病理について : 神経・精神疾患の神経病理学的研究(1)(<特集>脳と神経の研究V)

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Usual pathological reports on Japanese B encephalitis have been almost concerned with acute cases except for a few of subacute (delayed) and chronic stages, because the fates of their courses are mostly decided within a week at the longest. So there are still no neuropathological evidences to explain the mechanisms of the postencephalitic sequelae. Moreover, some questions which are related to the relapse or reinfection and latently persisting infection of Japanese B encephalitis are raised. In order to clear up these difficult problems, the authors investigate neuropathologically on the unusual autopsied cases of both two subacute (15 yrs., female, 37 days duration and 19 yrs., male, 44 days duration) and chronic (36 yrs., male, 7 and 1/2 yrs. duration) Japanese B encephalitides. The results are summarized as follows. 1) The histopathological characteristics of subacute stage are as shown under perivascular and pial lymphocytic infiltrations in more slight degree, occasionally mixed with a few number of plasma cells; less number of cellular nodules of loose nature; more pronounced diffuse proliferation of activated rod cells; advanced phagocytosis by increased gitter cells, occasionally accompanied with multinuclear giant cells; tissue softenings with a tendency to coalesce: calcareous deposits on the degenerated nerve cells; marked proliferation of gemistocytic astrocytes; the lesions tended to be localized in the thalamic nuclei, substantia nigra and caudate nucleus. 2) Parkinsonian syndrome and character changes, peculiar postencephalitic sequelae, are neuropathologically based upon the irreversible and widespread necrotic foci in the substantia nigra and thalamic nuclei. 3) The pathological findings shown in the chronic case suggest the presence of Japanese B encephalitis, in which the virus exerts mild infectious action on the central nervous system over a long period.
千葉大学の論文

亜急性および慢性日本脳炎の病理について : 神経・精神疾患の神経病理学的研究(1)(<特集>脳と神経の研究V)

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