脱髄性脳脊髄炎の臨床・病理学的研究(<特集>脳と神経の研究III)

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Seven autopsied cases of demyelinating encephalomyelitides are examined from the clinicopathological aspect. They comprise three cases of neuromyelitis optica, one case of Schilder's diffuse sclerosis, one case of transitional sclerosis (Poser & Van Bogaert) and two cases of disseminated encephalomyelitis (Table 1). The conclusions are as follows : 1. Neuromyelitis optica presents not only an acute and monophasic course, but a chronic and polyphasic one as multiple sclerosis. Intervals between the occurrence of optic sign and spinal symptom are various. Lesions are localized mainly on spinal cord and optic nerve, occasionally in the brain stem, cerebellum and cerebrum as tiny lesions. The lesions show typical tissue necrosis and pronounced mesenchymal proliferation with retarded reparatory organization by glial fibrils. 2. The clinical courses of Schilder's diffuse sclerosis are in general severe and rapid processes suggesting the lesion of occipital lobes, but in a few cases, the chief process originates in the frontal lobe of the bilateral hemispheres and shows a slow progression. Transitional sclerosis (Poser & Van Bogaert), disseminated-diffuse sclerosis, is considered as a main group, while the classic types of both multiple sclerosis and Schilder's diffuse sclerosis are rather of special type. 3. Disseminated encephalomyelitides with the vascular lesions, such as Behcet's syndrome and polyarteritis nodosa, show characteristic pathomorphological features supposed to be autoimmune mechanism. Regarding the pathogenesis of the demyelinating encephalomyelitides, the hypothesis is being carried out by the authors that the autoimmune mechanism would be the most important factor.
千葉大学の論文
1966-11-28

脱髄性脳脊髄炎の臨床・病理学的研究(<特集>脳と神経の研究III)

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