脳膜肉腫の発生と脳内移植腫瘍に関する実験的研究

概要

論文の詳細を見る
The production of meningeal sarcoma was attempted by 20-Methylcholanthrene crystals that were implanted in the left parietal areas of 73 hybrid mice brains. Meningeal sarcomas developed in eleven mice experimentally. The survival periods were from 121 days to 238 days after implantation of carcinogenic substance, and ratio of induction was 35.5%. The experimentally produced meningeal sarcomas were classified in the fibrous-(7 cases), the spindle cell-(2 cases) and the polymorphic cell-types (2 cases) histological- and histochemically. It seemed that the polymorphic cell sarcoma was the most immature and malignant, on the ground of not only the morphological findings, but intracellular RNA and DNA- increasing according to Methylgreen-Pyronine stain (Brachet's method). While it was considered about the developmental history of meninges and the classification of meningioma in many references, especially Globus's concept, it was concluded that the histogenesis of the produced tumors must be traced back to the primitive meningeal mesenchyme. The cerebral tissues surrounding the implanted carcinogenic substances were analysed histological- and histochemically, and it was supposed that atypically proliferating cells accompanied with increasing of intranuclear DNA and intracytoplasmic RNA in the granulomatous tissue should develop to the meningeal sarcoma. Microglial cells and multinuclinucleated giant cells phagocyted M-C pigments and inhibited the gliomatous growing certainly. After the intracerebral transplantations of the experimentally produced meningeal sarcoma, Fructose sarcoma, Sarcoma-180, Ehrlich's ascites carcinoma and Brown-Pearce rabbit carcinoma, the growing manners of tumor tissues and the histological attitude of surrounding nervous tissues, especially glial elements were studied as compared with one another. After the transplantation, the produced meningeal sarcoma revealed a nodal enlargement in the cerebral tissue with resemblance to the growth of the original tumor, and glial elements surrounding the growing tumor showed few reactive changes. Fructose sarcoma, some cases of Ehrlich's carcinoma and Brown-Pearce carcinoma (homo-transplantation) showed nodal growth in the cerebral tissue and produced the reticulum fibres less than the cases of subcutaneous transplantation. At S-180 and some cases of Ehrlich's carcinoma, the growing pattern in the brain was infiltrative one and ventricles were filled with the tumor cells. Hetero-transplantation of Brown-Pearce carcinoma in mice brains was unsuccessful. At seven days after transplantation, tumor cells showed a pyknosis and were phagocyted by proliferating microglial cells. Macroglial cells in brain tissue surrounding the growing tumor hypertrophied and proliferated remarkably at the cases of Fructose sarcoma, Ehrlich's carcinoma and Brown-Pearce carcinoma. Microglial cells also proliferated remarkedly in the surrounding tissue of Ehrlich's carcinoma.
千葉大学の論文
1963-05-28

脳膜肉腫の発生と脳内移植腫瘍に関する実験的研究

スポンサーリンク

概要

著者

関連論文

スポンサーリンク