アロキサン糖尿病に関する研究 : 特に唾液腺及び骨,軟骨系統の変化に就て
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概要
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Many studies on alloxan diabetes have been carried out since Goldner and Gomori discovered in 1943 that the injection of alloxan was able to induce continuous diabetes in animals. However, there are few systematic reports regarding the changes in endocrine glands, especially the salivary glands, in alloxan-diabetic animals. Moreover, studies on changes in the bone and cartilage system have hardly been performed. Now, in the present experiments in which diabetes had been developed by injecton of alloxan were classified into 3 groups in accordance with the degree of hyperglycemia, and their endocrine glands, especially the salivary glands, were investigated histologically, and elevation and duration of hyperglycemia were also investigated.At the same time, extract of salivary glands were prepared with physiologic saline solution containing 0.5% of hydrochloric acid by the method of Best and Scott, and then the effect of the extract on the blood sugar levels in normal rabbits was examined. For the purpose of coducting research on the boneand the cartilage system, epiphysis of the tibia, patella and vertebra were examined histologically and observations were made on the correlation between the changes in the bone system and the salivary glands. Results are as follows: 1) In the salivary glands of the alloxan-diabetic dogs, changes occurred were mostly regressive, showing degnerative and cystic atrophy of the striated tubules and degenerative atrophy of the acinar cells. These changes grew more marked in proportion to elevation and duration of the hyperglycemia. 2) In mild or recovered cases, there existed no evident hypertrophy and proliferation of the striated tubules and the acinar cells of the salivary glands. 3) The extracted fluid of the salivary glands manifested, unlike insulin, an action to raise, though slightly, blood sugar levels in normal rabbits rather than to lower them. 4) The results of the experiments as itemized above will prove that the salivary glands do not function in compensation for pancreas in the alloxan diabetic dogs. 5) In the bone and cartilage system, there occurred degeneration of the 'cartilage cells, poor formation of the columns of the calcified cartilage matrix and osteoporosis due to the increased irregular resorption with a decrease in the additional bone on the trabecula. 6) The above-mentioned findings on the bone system paralleled the changes in the salivary glands. Therefore, the auther has arrived at a conclusion that the regressive changes in the salivary glands which control various metabolisms as well as maintenance and proliferation of the mesenchymal systems play an important role in the occurrence of changes in the bone system in alloxan-diabetic dogs.
- 千葉大学の論文
- 1955-09-28
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- アロキサン糖尿病に関する研究 : 特に唾液腺及び骨,軟骨系統の変化に就て