Effects of Occlusion and Further Distension of Unilateral Pulmonary Artery with an Inflatable Balloon upon Systemic and Pulmonary Hemodynamics

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1) Unilateral pulmonary artery occlusion with an inflatable balloon was carried out in dogs, monitoring end-tidal CO2 concentration from the occluded lung as an indicator of the pulmonary blood flow.2) As the balloon was inflated gradually up to the complete occlusion, the pulmonary arterial pressure was elevated stepwise in parallel with stepwise reduction in the end-tidal CO2 concentration or CO2 output. The elevation in the mean pulmonary arterial pressure, which was observed consistently, was 72% above the control value with the right sided occlusion and 42% with the left, when the complete occlusion was accomplished.3) Although further inflation of the balloon was attempted to distend the pulmonary artery, no additional elevation in the pulmonary arterial pressure was observed.4) When a branch of the pulmonary artery or a lobar artery was occluded, an elevation of a lesser extent in degree in the pulmonary arterial pressure was obtained.5) No difference in changes in the pulmonary arterial pressure between the internal occlusion and the external ligation was seen.6) The systemic arterial pressure showed no consistent change during the procedure except for transient "initial drop" seen in most of the experiments.7) It was concluded that the elevation was solely due to its mechanical effect.
International Heart Journal刊行会の論文