Assay of Heparin in Plasma Using a Chromogenic Substrate and Its Clinical Applications

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概要

• 論文の詳細を見る

• The concentration of heparin in plasma was measured using a chromogenic substrate. It appeared that the measurement of heparin concentration in plasma was important in therapeutic control and evaluation of heparin. There was a correlation between the activated partial thromboplastin time (APTT) and heparin concentration in plasma, but since the gradients of regression line differed in each of the cases, measurement of APTT alone would give a different estimate of heparin concentration in each case. Fibrinopeptide A (FPA) is considered as the best indicator for evaluation of therapeutic effects of heparin. Therapeutic heparin concentrations were defined as ranging from 0.2 to 1.2IU/ml because the normalization of FPA was observed and there happened no hemorrhagic accidents in that range.

• International Heart Journal刊行会の論文

著者

• Nagata Hiroshi

  First Department of Surgery, Aichi Medical University

• Hasegawa Hiroshi

  First Department Of Surgery Nippon Medical School

• Murao Makoto

  First Department Of Medicine School Of Medicine Hokkaido University

• YAMAUCHI Masao

  First Department of Medicine, Hokkaido University School of Medicine

• MURAKOSHI Toshio

  First Department of Medicine, Hokkaido University School of Medicine

• OGUMA Yutaka

  First Department of Medicine, Hokkaido University School of Medicine

• TAKEI Hideaki

  First Department of Medicine, Hokkaido University School of Medicine

• SEYA Tsukasa

  First Department of Medicine, Hokkaido University School of Medicine

• MURAO Makoto

  First Department of Internal Medicine, Hokkaido University School of Medicine

• OGUMA Yutaka

  First Department of Internal Medicine, Hokkaido University School of Medicine

• TAKEI Hideaki

  First Department of Internal Medicine, Hokkaido University School of Medicine

• SEYA Tsukasa

  First Department of Internal Medicine, Hokkaido University School of Medicine

• MURAKOSHI Toshio

  First Department of Internal Medicine, Hokkaido University School of Medicine

• NAGATA Hiroshi

  First Department of Internal Medicine, Hokkaido University School of Medicine

• YAMAUCHI Masao

  First Department of Internal Medicine, Hokkaido University School of Medicine

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