Role of Dextran Sulfate in Urokinase Therapy and Evaluation of the Effects by Estimation of Plasmin Inhibitor, Fibrinogenolytic Degradation Products, and Fibrinolytic Degradation Products

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概要

• 論文の詳細を見る

• The present study was concerned with changes in APTT and coagulation-fibrinolytic inhibitors in 2 groups of patients receiving either UK with heparin or UK with heparin and dextran sulfate (DS).APTT just after UK treatment showed a significant prolongation in patients receiving combination treatment with DS, but contrarily a shortening in patients receiving those without DS. This result indicated the usefulness of DS combination in UK treatment.There was a marked difference between the responses of α2-PI and antiplasmin to the treatment, presumably as a result of immune complex formation of the α2-PI with plasmin. However, no marked difference in α2-PI and AT-III existed both just after and at 24 hours after UK treatment in patients receiving UK (240, 000 units) with both heparin and DS and those receiving UK (480, 000 units) with heparin. Those results suggest that the dosage of UK can be reduced by combination of DS.Successful UK treatment in clinical cases resulted in a decrease of α2-PI and an increase of fibrinogenolytic or fibrinolytic degradation products. For these reasons, effective UK treatment appears to require combination with DS and several treatment days under the condition with a decrease of α2-PI (50%) and fibrinogenolysis with fibrinolysis, which are followed by administrations of UK.

• International Heart Journal刊行会の論文

著者

• Nagata Hiroshi

  First Department of Surgery, Aichi Medical University

• Hasegawa Hiroshi

  First Department Of Surgery Nippon Medical School

• Murao Makoto

  First Department Of Medicine School Of Medicine Hokkaido University

• YAMAUCHI Masao

  First Department of Medicine, Hokkaido University School of Medicine

• MURAKOSHI Toshio

  First Department of Medicine, Hokkaido University School of Medicine

• OGUMA Yutaka

  First Department of Medicine, Hokkaido University School of Medicine

• TAKEI Hideaki

  First Department of Medicine, Hokkaido University School of Medicine

• SEYA Tsukasa

  First Department of Medicine, Hokkaido University School of Medicine

• MURAO Makoto

  First Department of Internal Medicine, Hokkaido University School of Medicine

• MURAO Makoto

  First Department of Medicine, Hokkaido University School of Medicine

• OGUMA Yutaka

  First Department of Internal Medicine, Hokkaido University School of Medicine

• TAKEI Hideaki

  First Department of Internal Medicine, Hokkaido University School of Medicine

• SEYA Tsukasa

  First Department of Internal Medicine, Hokkaido University School of Medicine

• MURAKOSHI Toshio

  First Department of Internal Medicine, Hokkaido University School of Medicine

• NAGATA Hiroshi

  First Department of Internal Medicine, Hokkaido University School of Medicine

• NAGATA Hiroshi

  First Department of Medicine, Hokkaido University School of Medicine

• YAMAUCHI Masao

  First Department of Internal Medicine, Hokkaido University School of Medicine

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