Experimental Studies on the Production of Pulmonary Infarction (IV):Effects of UK, Heparin, t-AMCHA or Ellagic Acid

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概要

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• Pulmonary infarction was produced by the infusion of rabbit blood clots on the 3rd day after the injection of minced rabbit thrombi, and, concurrently, UK, heparin, t-AMCHA, or ellagic acid was injected to evaluate the influences of these agents upon the frequency of production of pulmonary infarction. In addition, the coagulation-fibrinolytic observations were made during the course of these experiments.(1) The frequency of production of pulmonary infarction was 50% in the control group, while those in the UK-treated group, heparin-treated group, t-AMCHA-treated group, or ellagic acid treated group was 20%, 40%, 80%, and 60% respectively. UK and heparin seemed to be applicable drugs for clinical practice.(2) The prerequisites for production of pulmonary infarction from the results of venous blood examinations seemed to be formation of advanced secondary thrombosis under persistence of hypercoagulability and activa tion of secondary fibrinolysis which was not so intense as to fibrinolyze the secondary thrombi.(3) In the clinical application of UK, the dose should be determined theoretically in consideration of factors at the side of a patient and by fibrinolytic time from a patient plasma with TEG.

• International Heart Journal刊行会の論文

著者

• Hasegawa Hiroshi

  First Department Of Surgery Nippon Medical School

• KAKIZAKI Hironobu

  First Department of Medicine, Hokkaido University School of Medicine

• MURAO Makoto

  First Department of Internal Medicine, Hokkaido University School of Medicine

• MURAO Makoto

  First Department of Medicine, Hokkaido University School of Medicine

• MURATA Hajime

  First Department of Medicine, Hokkaido University School of Medicine

• WATANABE Nobuo

  First Department of Medicine, Hokkaido University School of Medicine

• WATANABE Naoyoshi

  First Department of Medicine, Hokkaido University School of Medicine

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