Experimental Studies on the Production of Pulmonary Infarction:Especially from Coagulative and Fibrinolytic Studies

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概要

• 論文の詳細を見る

• In this experiment, attempts were made to clarify the mechanism with which the pulmonary infarction occurs, from coagulofibrinolytic point of view. The following results were obtained.1) Injection of the human serum (2ml./Kg.) into the rabbits provoked a hypercoagulative state within 2min. after the injection, followed by a decrease afterward with accelerated fibrinolytic activity. The control level was resumed about 1 hour after the injection.2) Changes in the coagulofibrinolytic system induced by lycopodium spores infusion progressed slowly toward a marked hypercoagulative state with reduced fibrinolytic activity seen 2 to 3 days later. Injection of the blood clots at this time yielded a high mortality among the animals.However the pulmonary infarction tended to occur in the survived.3) Although natural liquefaction of the blood clots, when injected at the 5th day after the lycopodium spores infusion, was seen in the majority of the cases, intravenous injection of t-AMCHA in combination with the procedure produced the pulmonary infarction in 62.5% of the animals, and further addition of intravenous injection of the human serum yielded the highest rate (88.9%) in producing the infarct.The tissue activator was a high activity in the infarcted area for 6 hours after the blood clot injection, but showed a decrease below control level after 3 to 5 days.4) The same procedure performed I month or later after the lycopodium infusion failed to produce the infarct.5) It is concluded from these observations that the following 3 factors, cessation of the blood flow in the collateral vessels brought by repeated microembolization as can be obtained experimentally by the lycopodium infusion, hypercoagulative state in the blood, and reduction of fibrinolytic activity, are sine qua non in producing the pulmonary infarction. Embolization of the pulmonary artery with large embolus or emboli, and injury in the capillary beds as might be brought about by a heterologous serum injection are additional factors in the occurrence of the infarcts.

• International Heart Journal刊行会の論文

著者

• Hasegawa Hiroshi

  First Department Of Surgery Nippon Medical School

• KAKIZAKI Hironobu

  First Department of Medicine, Hokkaido University School of Medicine

• MURAO Makoto

  First Department of Internal Medicine, Hokkaido University School of Medicine

• WATANABE Nobuo

  First Department of Medicine, Hokkaido University School of Medicine

• WATANABE Naoyoshi

  First Department of Medicine, Hokkaido University School of Medicine

• KAKIZAKI Hironobu

  First Department of Medicine, Hokkaido University, School of Medicine

• KAWAI Terukuni

  First Department of Medicine, Hokkaido University, School of Medicine

• WATANABE Naoyoshi

  First Department of Medicine, Hokkaido University, School of Medicine

• MURAO Makoto

  First Department of Medicine, Hokkaido University, School of Medicine

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