Proteolysis of myosin and troponin in human myocardium of elderly subjects.

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概要

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• Actomyosin was prepared from human myocardium and its protein composition was examined by SDS-polyacrylamide gel electrophoresis. For some preparations, particularly actomyosin isolated from elderly subjects, a high molecular weight (HMW) band (identified as a breakdown product of myosin heavy chain) appeared, while the troponin-T subunit decreased. Myofibril associated protease (MFP) activity showed no significant difference as a function of proteolysis. In agreement with the proteolysis of troponin-T and myosin, the Ca2+ sensitivity of Mg2+-ATPase activity decreased while the extent of the stimulation of Ca2+-ATPase by N-ethylmaleimide remained unchanged. This type of proteolysis would affect the Ca2+-dependent regulation of muscle contraction but not the contractility per se.

• International Heart Journal刊行会の論文

著者

• Matoba Ryoji

  Department Of Forensic Medicine Osaka University School Of Medicine

• Wakasugi Choei

  Department Of Legal Medicine Osaka University Medical School

• Yoshida Ken-ichi

  Department Of Agrobioscience Graduate School Of Agricultural Science Kobe University

• MATOBA Ryoji

  Department of Legal Medicine, Saga Medical College

• HANAFUSA Tohru

  Department of Legal Medicine, Osaka University Medical School

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