Energetics of the time-varying elastance model, a visco-elastic model, Matches Mommaerts' unifying concept of the fenn effect of muscle.
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概要
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It is generally believed that the Fenn effect contradicts all viscoelastic models of muscle, including the new elastic body and the time-varying elastance models. Although it is clear that the new elastic body model can be discarded, the Fenn effect does not preclude the time-varying elastance model. Although no visco-elastic models can simulate the extra energy utilization for work above the level of the energy utilized for the maximal isometric contraction, the extra energy observed by Fenn is not generally observed, even in skeletal muscles. However, work-related extra energy utilization, above the isometric energy utilization at equivalent force (Mommaerts' unifying concept of the Fenn effect), is generally observed in both skeletal and cardiac muscles. This unifying concept of the Fenn effect in cardiac muscle can be simulated by a simple time-varying elastance model. This study demonstrates the essential difference in energetics between the new elastic body model and the time-varying elastance model.
- International Heart Journal刊行会の論文
著者
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SUGA Hiroyuki
Department of Cardiac Physiology, National Cardiovascular Center Research Institute
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SUGA Hiroyuki
Department of Cardiovascular Dynamics, National Cardiovascular Center (NCVC) Research Institute
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