Calcium kinetics and energetics in myocardium. Simulation study.
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概要
- 論文の詳細を見る
We carried out a simulation study to obtain insight into the relation between calcium (Ca2+) transients and energy for handling Ca2+ in excitation-contraction (EC) coupling. The simulation incorporated basic Ca2+ kinetics among total released Ca2+ from sarcoplasmic reticulum (SR), myoplasmic free Ca2+ ion concentration, and troponin (Tn)-Ca complex concentration ([TnCa]). The total Ca2+ released from the SR was arbitrarily set as an impulse and three rate constants were used for Ca2+ binding to Tn, Ca2+ dissociation from Tn, and Ca2+ uptake by SR. The results showed that the peak Ca2+ transient varies widely as a reciprocal of the Ca2+ sensitivity of the contractile machinery, despite constant total released Ca2+ and hence, a constant energy for Ca2+ handling. This result suggests a disproportate relationship between the magnitude of Ca2+ transients and the energy for Ca2+ handling when the Ca2+ sensitivity of contractile machinery changes.
- International Heart Journal刊行会の論文
著者
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Yaku Hitoshi
Department Of Cardiovascular Dynamics National Cardiovascular Center Research Institute
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TAKASAGO Toshiyuki
Department of Cardiovascular Dynamics, National Cardiovascular Center
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FUTAKI SHIHO
Department of Cardiovascular Dynamics National Cardiovascular Center Research Institute
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Goto Yoichi
Department Of Cardiology National Cardiovascular Center
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Kawaguchi Osamu
Department Of Applied Chemistry Faculty Of Engineering Saitama University
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SUGA Hiroyuki
Department of Cardiac Physiology, National Cardiovascular Center Research Institute
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HATA Katsuya
Department of Cardiovascular Dynamics, National Cardiovascular Center
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HATA Katsuya
Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Suita
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KAWAGUCHI Osamu
Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Suita
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YAKU Hitoshi
Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Suita
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TAKASAGO Toshiyuki
Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Suita
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Yaku Hitoshi
Department of Cardiovascular and Thoracic Surgery, Kyoto Prefectural University of Medicine
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