Inhibition of development of tolerance to nitroglycerin by preventive administration of N-acetylcysteine in rats.
スポンサーリンク
概要
- 論文の詳細を見る
The efficacy of N-acetylcysteine in reversing nitrate tolerance has been controversial. This study examined whether continuous administration of N-acetylcysteine, a sulfhydryl compound, can prevent the development of tolerance to nitroglycerin; its acute effects on developed tolerance were also assessed. Rats were treated with subcutaneous injections of 1) 100mg/kg nitroglycerin, 2) 100mg/kg nitroglycerin and 700mg/kg N-acetylcysteine, 3 times a day for 3 days. The sensitivity to nitroglycerin was studied in aortic preparations. The degree of developed tolerance to nitroglycerin was partially inhibited by simultaneous injection of N-acetylcysteine. Subsequent in vitro preincubation of aortic strips with nitroglycerin (10-5M) reduced the subsequent nitroglycerin sensitivity of vessels from rats treated with nitroglycerin and N-acetylcysteine; sensitivity returned to the initial control level after in vitro preincubation with N-acetylcysteine. The nitroglycerin sensitivity of vessels from rats treated only with nitroglycerin, though, was not affected by in vitro preincubation with N-acetylcysteine. In conclusion, N-acetylcysteine is not effective in reversing the high degree of tolerance developed to nitroglycerin. However, continuous administration of Nacetylcysteine is effective in preventing the development of nitroglycerin tolerance.
- International Heart Journal刊行会の論文
著者
-
Moroi Masao
Third Department Of Internal Medicine Toho University Ohashi Hospital
-
Ohno Minoru
Department Of Cardiology Toranomon Hospital
-
Ochiai Masahiko
Department Of Chemitsry School Of Science And Engineering Waseda University
-
Tsuneyoshi Hideo
Department Of Internal Medicine Odaira-memorial Tokyo Hitachi Hospital
-
Hara Kazuhiro
Department Of Applied Science Faculty Of Engineering 36 Kyushu University
-
MOROI Masao
Third Department of Internal Medicine, Faculty of Medicine, Toho University
-
AKATSUKA Nobuharu
Department of Internal Medicine, Faculty of Medicine, University of Tokyo
-
HARA Kazuhiro
Department of Internal Medicine, Faculty of Medicine, University of Tokyo
-
TSUNEYOSHI Hideo
Department of Internal Medicine, Faculty of Medicine, University of Tokyo
-
OHNO Minoru
Department of Internal Medicine, Faculty of Medicine, University of Tokyo
関連論文
- Age-Induced Reduction in Mitochondrial Manganese Superoxide Dismutase Activity and Tolerance of Macrophages Against Apoptosis Induced by Oxidized Low Density Lipoprotein
- Molecular Mechanism of Moderate Insulin Resistance in Adiponectin-Knockout Mice
- Vascular relaxing mechanism of OPC-18790.
- DISSOCIATION OF NITRIC OXIDE-INDUCED RELAXATION FROM cGMP PRODUCTION IN NITROGLYCERIN TOLERANT BLOOD VESSELS
- Successful Catheter Intervention for Acute Coronary Syndrome in a Patient with Antiphospholipid Syndrome
- Genetic Analysis in a Patient With Recurrent Cardiac Myxoma and Endocrinopathy
- -0901- A LONG ACTING SOMATOSTATIN ANALOG, OCTREOTIDE, INHIBITS ENDOTHELIN-1 RELEASE FROM CULTURED BOVINE ENDOTHELIAL CELLS(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- Partical Type of Common Atrioventricular Canal Defect Associated with Mitral Stenosis
- Carvedilol Therapy Improved Left Ventricular Function in a Patient With Arrhythmogenic Right Ventricular Cardiomyopathy
- PJ-212 Modern X-ray Equipment is Beneficial to Patients Treated by Catheter Ablation : Evaluation by New Radiosensitive Indicator(Arrhythmia, therapy-18, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- First Experience of Using New Adaptive Servo-Ventilation Device for Cheyne-Stokes Respiration With Central Sleep Apnea Among Japanese Patients With Congestive Heart Failure : Report of 4 Clinical Cases
- PJ-469 Predictive Factors of a Favorable Responder after Renal Artery Stenting in Patients with Renal Artery Stenosis(PJ079,Peripheral Circulation/Vascular Disease (Therapy) 2 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanes
- PJ-296 Heterozygous PPAR γ Deficient Mice Showed Increased Neointima Formation with Vascular Smooth Muscle Cell Proliferation in Response to Cuff Injury(Atherosclerosis, Basic 3 (IHD) : PJ50)(Poster Session (Japanese))
- OJ-444 Intramyocardial Injection of Fibroblast Growth Factor-2 Plus Heparin Suppresses Cardiac Failure Progression in Rats with Hypertensive Heart Disease(Heart Failure, Basic 3 (M) : OJ54)(Oral Presentation (Japanese))
- Lack of Insulin Receptor Substrate-2 Is a Link between Insulin Resistance and an Increased Intima of the Vessel in Mice
- Intramyocardial injection of fibroblast growth factor-2 suppresses cardiac failure progression in dilated cardiomyopathic hamsters
- Vascular Intima Formation in Insulin Receptor Substrate-2 Deficient Mice
- OE-057 Manganese Superoxide Dismutase Polymorphism is Associated with Acute Coronary Syndrome(Acute coronary syndrome, basic/clinical-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Altered Manganese Superoxide Dismutase Activity Resulting from Alanine/Valine Polymorphism Affects the Apoptosis of Macrophages Causude by Oxidized Low Density Lipoprotein(Apoptosis/Necrosis/Regeneration 1 (M), The 69th Annual Scientific Meeting of the Ja
- PJ-375 The Heme oxygenase-Carbon Monoxide Pathway Protects against Hypoxia-Induced Cell Death of Bovine Endothelial Cells through Inhibition of Oxidative Stress(Apoptosis/Necrosis/Regeneration 1 (M) : PJ63)(Poster Session (Japanese))
- FRS-052 Activity of Manganese Superoxide Dismutase (MnSOD) in mitochondria is closely related to MnSOD polymorphism.(Oxidative Stress, Autonomic Function and Peripheral Vascular Diseases (H) : FRS7)(Featured Research Session (English))
- OE-118 Efficacy of 64-slice Multidetector Computed Tomography in Diabetic Patients with Suspected Coronary Artery Disease(CT/DSA-01, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-219 Direct Infusion of Nicorandil Distal to Infarct Related Artery Prior to Reperfusion in Patients with Acute Myocardial Infarction.(Acute Myocardial Infarction, Clinical (Diagnosis/Treatment) 12 (IHD) : PE38)(Poster Session (English))
- EXPRESSION OF MUC-1 mRNA IN MOUSE UTERINE EPITHELIAL CELL LINES(Endocrinology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- A Soft Acoustic Mode in the Ferroelastic Phase Transition of LaNbO_4
- 0965 HYPOXIA INDUCES VASCULAR ENDOTHELIAL GROWTH FACTOR IN CULTURED HUMAN ENDOTHELIAL CELLS
- PJ-586 Central Sleep Apnea and Chronic Atrial Fibrillation without Systolic Heart Failure(PJ098,Obesity/SAS (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Angiotensin II-Induced Upregulation of Fibrosis-Related Gene Is Suppressed by the Iron Chelation
- Angiotensin II downregulates renal expression of anti-aging gene, kiotho, and exogenous klotho gene transfer ameliorates angiotensin II-induced renal damage
- Elastic Anomaly and Glass Transition in Dehydrated Egg White Gel
- Difference in Low Frequency Raman Spectra between Dehydrated Egg White and the Dehydrated Heat-Treated Gel
- Change in the Low-Lying Raman Scattering Spectrum in the Glass Transition of Dehydrated Polyacrylamide Gel
- Raman Peak in Low-Frequency Region of Dehydrated Egg-White Gel
- Raman Scattering Study during the Dehydration Process of Polyacrylamide Gel
- Investigations of Pressure and Temperature Effects on Gelation Process of Egg White by Time-Resolved Turbidimetric Measurements
- A Study of Crystallites in Obliquely Deposited Iron Films by Ellipsometry
- Correspondence of Optical Anisotropy to Magnetic Anisotropy in Iron Films
- 3 Sleep Disordered Breathing and Aortic Diseases(Sleep Apnea Syndrome as a Risk of Cardiovascular Disease,Topic 2 (TP-2) (H),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Bi-Level Positive Airway Pressure Ventilation for Treating Heart Failure With Central Sleep Apnea That is Unresponsive to Continuous Positive Airway Pressure
- PJ-933 Improvement of left ventricular systolic function by continuous positive airway pressure in patients with heart failure and obstructive sleep apnea(Heart failure, clinical(22)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Ja
- PJ-711 The Predictive Factors of Manifested Sick Sinus Syndrome with Atrial Flutter(PJ119,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 7 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-383 Primary- and Mid-term Outcomes of Drug-eluting Stent Implantation Follwing Rotational Athelectomy in the Calcified Lesions of Hemodialysis Patients(PE064,Coronary Revascularization, PCI (DES) 6 (IHD),Poster Session (English),The 73rd Annual Scienti
- PE-327 How to conquer the gap between caudiopulmonary resuscitation training and the real-world resuscitation?(Emergency care/CPR(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Chlamydia Pneumoniae and Cytomegarovirus May Play a Pathogenic Role in Acute Coronary Syndrome (Histopathological Assessment of Tissue Specimens)
- The efficacy of bare metal stent implantation for patients with acute myocardial infarction in the drug-eluting stent era
- Primary and mid-term outcome of sirolimus-eluting stent implantation with angiographic guidance alone
- Coronary Artery Spasm and the Polymorphisms of the Endothelial Nitric Oxide Synthase Gene
- Effect of p53 Deficiency on External Vascular Cuff-Induced Neointima Formation
- Effects of disruption of p53 gene on vascular neointima formation
- Change of Temperature and Elastic Stiffness during Dehydration Process of Polyacrylamide Gel
- -0317- Parathyroid Hormone-Related Protein is Expressed in Atherosclerotic Lesion and Inhibits the Development of Cuff-Induced Intimal Thickening in Rat Femoral Artery(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- ANGIOTESIN II DECREASES cGMP LEVEL VIA AT2 RECEPTOR IN THE NEOINTIMA OF RAT AORTA AFTER BALLOON INJURY
- EFFECT OF ENDOTHELINE ON ANGIOTENSIN CONVERTING ENZYME ACTIVITY IN CULTURED VASCULAR SMOOTH MUSCLE CELLS
- EFFECT OF CAPTOPRIL ON ACETYLCHOLINE-INDUCED RELAXATION IN THE PRESENCE OF NITROGLYCERIN TOLERANCE IN ISOLATED RABBIT AORTA
- -1239-ENDOTHELIUM-DEPENDENT VASCULAR SMOOTH MUSCLE RELAXATION RESPONSE ON NITROGLYCERIN-TOLERANT BLOOD VESSELS : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -1238-VASCULAR SMOOTH MUSCLE RELAXATION BY α-ADRENOCEPTOR BLOCKING ACTION OF DENOPAMINE : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- OE-327 Nebulized Delivery of Nano-Scale All-trans Retinoic Acid Particles Inhibited Monocrotaline-induced Pulmonary Hypertension in Rats(Pulmonary circulation-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Observation of Ferroelastic Domains in LaNbO_4 by Micro-Raman Spectroscopy
- Abnormal iron deposition in the angiotensin II-induced hypertensive rats : A possible link with cardiac damage
- Different Regulation of Heat Shock Proteins in the Heart of Angiotensin II-induced Hypertensive Rats
- Platelet Aggregability Under Shear is Enhanced in Patients With Unstable Angina Pectoris Who Developed Acute Myocardial Infarction
- IS082 Efficasy of Transradial Primary Stenting in Patiests with Acute Myocardial Infarction
- Relationship between serum 1,25-dihydroxyvitamin D and mortality in patients with pre-dialysis chronic kidney disease
- 1052 EFFECT OF AGE ON THE PHARMACOKINETICS OF ORAL ISOSORBIDE 5-MONONITRATE AND DINITRATE IN PATIENTS WITH ISCHEMIC HEART DISEASE
- Characteristics of Revascularization Treatment for Arteriosclerosis Obliterans in Patients With and Without Hemodialysis
- Scanning Tunneling Microscope Observation of a Polar Liquid Crystal and Its Computer Simulation
- Small-Angle Neutron Scattering Observation of Aqueous Suspension of Microcrystalline Cellulose
- Some Features in Gel Drying Process and Dehydrated Substances
- Transformation of Egg-White Glass into Partially Crystallized Glass Induced by Heat Treatment and Gamma-Ray Irradiation
- Simultaneous Time-Resolved Measurements of Weight and Small-Angle X-Ray Scattering of Heat- and Pressure-Treated Egg White during Gel-to-Glasslike Transition
- Variations of Mechanical Properties in Egg White during Get-to-Glasslike Transition
- Solvent-Substitution Effects on Weight and Volume Changes during the Desiccation Process of Egg-White Gel
- Density Variation in Heat- and Pressure-Treated Egg White during Gel-to-Glass-like Transition
- Structure of the Stripe Domains of Anomalous Magnetic Thin Films
- PE-420 Lipid Accumulation and Induction of TGF-β1 in the Kidney of Angiotensin II-infused Rat(Kidney/Renal circulation-2 (H) PE70,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Co-localization of Lipid Droplets and TGF β1 and PDGF-B in the Kidney of Rat Model of Angiotensin II-Induced Hypertension (Hypertension, Basic 4(H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Role of Aberrant Iron Homeostasis in the Upregulation of Transforming Growth Factor-β1 in the Kidney of Angiotensin II-Induced Hypertensive Rats
- Alcohol-induced Ventricular Fibrillation in Brugada Syndrome
- OE-005 Crush stenting may not be effective for distal Unprotected Left Main Coronary Artery Stenosis(Coronary revascularization, PCI(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Association of the manganese superoxide dismutase polymorphism with vasospastic angina pectoris
- Age-related changes in plasma androgen levels and their association with cardiovascular risk factors in male Japanese office workers
- Two cases of acute coronary syndrome that occurred by preoperative discontinuation of antiplatelet therapy in the chronic phase after stent implantation
- Sinus Histiocytosis with Massive Lymphadenopathy Associated with Malignant Lymphoma
- Usefulness of rotational atherectomy for the implantation of drug-eluting stents in the calcified lesions of hemodialysis patients
- Optical Measurements during Gelation Process of Muscle Protein under High Pressure
- AFM Observation of Ferroelectric Domains on TGS Cleavage Surface
- Direct Observation of Domaim Structures in Triglycine Sulfate by Atomic Force Microscope
- PJ-365 Initial and Long-term Outcome of Elective PCI for Unprotected Left Main Coronary Artery (UPLMCA) Stenosis in DES Era(Coronary revascularization, PCI-17 (IHD) PJ62,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japan
- Surface Wave Measurerments during Gelation Process of Tungstic Acid
- Propagating Properties of Surface Wave in Sol-Gel Transition of Tungstic Acid
- Propagating Property of Surface Waves and Viscoelasticity near the Gelation Point
- Gelation and Glass Transition in Thermosetting Process of Epoxy Resin
- Observation of Transmitted Light Spectra during Gelation Process of Actomyosin
- Correlation between the Photochromic Enhancement in Tungstic Acid and the O-C-H Bond irn Additives
- Dielectric and Ferroelectric Hysteresis Loop Measurements for Ultrathin VDF/TrFE Copolymer Films Evaporated Under Electric Field
- Evolution of Light Transmissivity of Tungstic Acid during Gelation
- 1,4-Dihydroxylation of 1,3-Conjugated Dienes Promoted by the Pt(III) Dinuclear Complex
- Inhibition of development of tolerance to nitroglycerin by preventive administration of N-acetylcysteine in rats.
- Endothelin-1 Concentrations in Pericardial Fluid Are More Elevated in Patients with Ischemic Heart Disease Than in Patients With Nonischemic Heart Disease
- Concentrations of Hepatocyte Growth Factor, Basic Fibroblast Growth Factor, and Vascular Endothelial Growth Factor in Pericardial Fluid and Plasma