Concentrations of Hepatocyte Growth Factor, Basic Fibroblast Growth Factor, and Vascular Endothelial Growth Factor in Pericardial Fluid and Plasma
スポンサーリンク
概要
- 論文の詳細を見る
Some angiogenic factors, including hepatocyte growth factor (HGF), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF), have been reported to promote angiogenesis and improve myocardial perfusion in experimental models of ischemic heart disease. These factors are produced in various tissues, including myocardium. We measured the concentrations of HGF, bFGF, and VEGF by enzyme-linked immunosorbent assay in plasma and in pericardial fluid sampled during open heart surgery (12 patients with ischemic heart disease and 17 with nonischemic heart disease). HGF levels were significantly higher in plasma than in pericardial fluid (12.0 ± 1.8 versus 0.26 ± 0.04 ng/mL, P < 0.0001). On the other hand, bFGF levels were significantly higher in pericardial fluid than in plasma (243.5 ± 50.9 versus 49.6 ± 7.8 pg/mL, P = 0.009). VEGF levels were not significantly different between pericardial fluid and plasma (47.2 ± 17.6 versus 24.5 ± 3.6 pg/mL, P = 0.23). Concentrations of angiogenic factors in pericardial fluid and in plasma were not significantly different between patients with ischemic and nonischemic heart disease. These results suggest that the production, secretion, and kinetics of HGF, bFGF, and VEGF are different. These angiogenic factors may have different pathophysiologic roles.
- International Heart Journal刊行会の論文
著者
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Ebine Kunio
Department of Cardiocascular Surgery, Toho University School of Medicine
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Moroi Masao
Third Department of Internal Medicine, Toho University School of Medicine, Ohashi Hospital
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Ishikawa Michiro
Third Department of Internal Medicine, Toho University School of Medicine, Ohashi Hospital
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Fukazawa Masayuki
Third Department of Internal Medicine, Toho University School of Medicine, Ohashi Hospital
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Moroi Masao
Third Department Of Internal Medicine Toho University Ohashi Hospital
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Namiki Atsushi
Third Department Of Internal Medicine Toho University School Of Medicine Ohashi Hospital
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Yamaguchi Tetsu
Third Department Of Internal Medicine Ohashi Hospital Toho University School Of Medicine
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Ebine Kunio
Department of Cardiovascular Surgery, Toho University School of Medicine, Ohashi Hospital
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Kubota Tetsuya
Third Department of Internal Medicine, Toho University School of Medicine, Ohashi Hospital
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