Endothelin-1 Concentrations in Pericardial Fluid Are More Elevated in Patients with Ischemic Heart Disease Than in Patients With Nonischemic Heart Disease
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概要
- 論文の詳細を見る
There is epidemiologic evidence that the prognosis of patients with nonischemic heart failure is better than that for patients with ischemic heart failure. In addition, studies have revealed that patients with ischemic heart failure show a poorer response to medical therapy. However, the pathophysiologic difference between ischemic and nonischemic heart disease is unclear. To clarify this point, we measured atrial natriuretic peptide, brain natriuretic peptide, angiotensin II, endothelin (ET)-1, interleukin-1β, interleukin-6, tumor necrosis factor (TNF)-α, soluble TNF receptor I, and soluble TNF receptor II concentrations in plasma and pericardial fluid in patients with ischemic or nonischemic heart disease undergoing cardiac surgery. The pericardial ET-1 concentration in patients with ischemic heart disease was statistically greater than that in patients with nonischemic heart disease (about 1.5-fold), although no difference was found in the plasma ET-1 concentration. These findings suggest that the production and secretion of ET-1 from the myocardium in patients with ischemic heart disease are augmented to a greater extent than in patients with nonischemic heart disease. This result may lead to a greater understanding of the pathophysiology of ischemic heart disease.
- International Heart Journal刊行会の論文
著者
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Ebine Kunio
Department of Cardiocascular Surgery, Toho University School of Medicine
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Aikawa Jo
Third Department Of Internal Medicine Toho University Ohashi Hospital
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Ishikawa Michiro
Third Department of Internal Medicine, Toho University School of Medicine, Ohashi Hospital
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Fukazawa Masayuki
Third Department of Internal Medicine, Toho University School of Medicine, Ohashi Hospital
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Moroi Masao
Third Department Of Internal Medicine Toho University Ohashi Hospital
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Namiki Atsushi
Third Department Of Internal Medicine Toho University School Of Medicine Ohashi Hospital
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Kubota Tetsuya
Third Departmnt Of Internal Medicine Ohashi Hospital Toho University
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Yamaguchi Tetsu
Third Department Of Internal Medicine Ohashi Hospital Toho University School Of Medicine
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Aikawa Jo
Third Department of Internal Medicine, Toho University School of Medicine, Ohashi Hospital
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Kubota Tetsuya
Third Department of Internal Medicine, Toho University School of Medicine, Ohashi Hospital
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