Hemostatic and Fibrinolytic Activation Is Less Following Cutting Balloon Angioplasty of the Coronary Arteries
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概要
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Recent studies have shown that percutaneous coronary intervention (PCI) activates systemic hemostatic activity, reflecting platelet activation and thrombin formation in the coronary arteries. The present study compared systemic levels of hemostatic markers induced by plain old balloon angioplasty (POBA), coronary stenting (STENT), and cutting balloon (CB) angioplasty. Sixty-one patients with stable angina pectoris, who underwent elective PCI or diagnostic coronary angiography (CAG) alone, were investigated. Patients who underwent PCI were divided into the POBA group (n = 11), the STENT group (n = 27), and the CB group (n = 11). Patients who underwent CAG alone were assigned to the CAG group (n = 12). Blood samples were collected before, 24 hours after, and 3 days after PCI or CAG. Plasma concentrations of prothrombin fragment 1+2 (F1+2), fibrinopeptide A (FPA), thrombin-antithrombin III complex (TAT), and plasminogen activator inhibitor-1 (PAI-1) were measured. In the CB group, the F1+2 (1.23 ± 0.4 nmol/L) level 3 days after PCI was significantly smaller than that of the POBA group (2.37 ± 0.5 nmol/L) (P < 0.05). The FPA (1.81 ± 0.9 ng/mL), TAT (3.36 ± 1.2 ng/mL) and PAI-1 (23.0 ± 4.1 ng/mL) levels in the CB group 3 days after PCI were significantly smaller than those of the POBA group (P < 0.05, respectively) and STENT group (P < 0.05, respectively), but similar to the CAG group. Systemic hemostasis is activated to a greater extent after POBA and stenting than it is after CB angioplasty of the coronary arteries. This may contribute to the favorable long-term outcome of CB angioplasty.
著者
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Yamaguchi Tetsu
Third Departmnt of Internal Medicine, Ohashi Hospital, Toho University
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Kobayashi Nobuyuki
Third Department of Internal Medicine,Toho University Ohashi Hospital
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Asahara Toshiyuki
Third Department of Internal Medicine,Toho University Ohashi Hospital
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Nakamura Masato
Third Department of Internal Medicine,Toho University Ohashi Hospital
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Nakamura Masato
Third Department Of Internal Medicine Chiba University School Of Medicine
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Nakamura Masato
東邦大学医療センター大橋病院 循環器内科
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Namiki Atsushi
Third Department of Internal Medicine, Toho University School of Medicine, Ohashi Hospital
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Toma Hiroko
Third Department of Internal Medicine, Toho University School of Medicine, Ohashi Hospital
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Matsuda Ken-ichi
Third Department of Internal Medicine, Toho University School of Medicine, Ohashi Hospital
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Hara Hidehiko
Third Department of Internal Medicine, Toho University School of Medicine, Ohashi Hospital
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Hara Hisao
Third Department of Internal Medicine, Toho University School of Medicine, Ohashi Hospital
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Soumitsu Yasunari
Third Department of Internal Medicine, Toho University School of Medicine, Ohashi Hospital
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Asahara Toshiyuki
西吾妻福祉病院
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Hara Hisao
東邦大学医療センター大橋病院 循環器内科
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Hara Hidehiko
東邦大学医療センター大橋病院 循環器内科
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Hara Hidehiko
Third Department Of Internal Medicine Toho University School Of Medicine Ohashi Hospital
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Namiki Atsushi
Third Department Of Internal Medicine Toho University School Of Medicine Ohashi Hospital
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Yamaguchi Tetsu
Third Department Of Internal Medicine Ohashi Hospital Toho University School Of Medicine
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Asahara Toshiyuki
Third Department of Internal Medicine, Toho University School of Medicine, Ohashi Hospital
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