Presence and Severity of Chlamydia pneumoniae and Cytomegalovirus Infection in Coronary Plaques Are Associated With Acute Coronary Syndromes
スポンサーリンク
概要
- 論文の詳細を見る
Although an association between Chlamydia pneumoniae (Cpn) or Cytomegalovirus (CMV) infection and coronary atherosclerosis has been reported, such an association is less clear for acute coronary syndromes (ACS). The purpose of this study was to investigate the pathogenic roles of Cpn and CMV infection of coronary plaques in ACS. We divided 38 coronary plaque specimens obtained from 38 patients who underwent directional coronary atherectomy or thrombectomy into an ACS group (n = 21) and a non-ACS group (n = 17). Cpn and CMV in specimens were stained using immunohistochemical techniques and analyzed quantitatively. The detection rate for either Cpn- or CMV-positive cells in ACS patients was slightly higher compared with non-ACS patients. Detection rates for both Cpn- and CMV-positive cells were significantly higher in ACS patients than in non-ACS patients (P = 0.010). Furthermore, the density of Cpn- and CMV-positive cells in plaques was significantly higher in ACS patients than in non-ACS patients (P < 0.003). The results indicate that the presence and severity of Cpn and CMV infection in coronary plaques are greater in patients with ACS compared with non-ACS patients. We conclude that infection with Cpn and CMV in coronary plaques may be involved in the pathogenesis of ACS.
- インターナショナル・ハート・ジャーナル刊行会の論文
著者
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MOROI MASAO
Division of Cardiovascular Medicine, Toho University, Ohashi Hospital
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HARA Hidehiko
Division of Cardiovascular Medicine, Toho University Ohashi Medical Center
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Hara Hisao
東邦大学医療センター大橋病院 循環器内科
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Hara Hidehiko
東邦大学医療センター大橋病院 循環器内科
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Hara Hidehiko
Division Of Cardiovascular Medicine Toho University Ohashi Medical Center
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Liu Ruiqin
Division of Cardiovascular Medicine, Toho University Ohashi Medical Center
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Yamamoto Masato
Division of Cardiovascular Medicine, Toho University Ohashi Medical Center
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Kubota Tetsuya
Division of Cardiovascular Medicine, Toho University Ohashi Medical Center
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Ono Tsuyoshi
Division of Cardiovascular Medicine, Toho University Ohashi Medical Center
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Funatsu Atsushi
Division of Cardiovascular Medicine, Toho University Ohashi Medical Center
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Komatsu Hiroki
Division of Cardiovascular Medicine, Toho University Ohashi Medical Center
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Tsuji Takahiro
Division of Cardiovascular Medicine, Toho University Ohashi Medical Center
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Hara Hisao
Division of Cardiovascular Medicine, Toho University Ohashi Medical Center
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Nakamura Masato
Division of Cardiovascular Medicine, Toho University Ohashi Medical Center
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Hirai Hironori
Division of Cardiovascular Medicine, Toho University Ohashi Medical Center
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Yamaguchi Tetsu
Director of Toranomon Hospital
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Moroi Masao
Division Of Cardiovascular Medicine Toho University Medical Center Ohashi Hospital
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Ono Tsuyoshi
Division Of Cardiovascular Medicine Toho University Ohashi Medical Center
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Hara Hisao
Division Of Cardiovascular Medicine Toho University Ohashi Hospital
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Yamamoto Masato
Division Of Basic And Translational Research Department Of Surgery University Of Minnesota
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Nakamura Masato
Division Of Cardiology Third Department Of Medicine Toho University School Of Medicine
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Kubota Tetsuya
Division Of Cardiovascular Medicine Ohashi Hospital Toho University School Of Medicine
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