Improvement of Postprandial Hyperglycemia Has a Positive Impact on Epicardial Flow of Entire Coronary Tree in Acute Coronary Syndromes Patients
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概要
- 論文の詳細を見る
Background Recent studies have shown that a global flow abnormality affects the entire coronary tree in patients with acute coronary syndrome (ACS), and that it is associated with adverse outcomes. Postprandial hyperglycemia is also thought to promote coronary endothelial dysfunction, as well as the release of inflammatory and vasoconstrictive factors. This study used the corrected Thrombolysis In Myocardial Infarction frame count (CTFC) to investigate whether optimal control of postprandial hyperglycemia improves pan-coronary flow. Methods and Results Eighty ACS patients with postprandial hyperglycemia who had successful coronary intervention and who had undergone a 75-g oral glucose tolerance test (OGTT) were included. A second OGTT and angiogram were performed 8 months after procedures. The patients were divided according to postprandial glycemia after the second 75-g OGTT; optimal postprandial hyperglycemia was defined as a 2-h blood glucose concentration <7.8mmol/L. Changes in the CTFC of culprit/non-culprit arteries, glucose response, and other clinical variables were compared. Forty patients improved to an optimal control at 8 months. In the culprit artery, the 8-month angiogram revealed a significantly improved CTFC among those with optimal control compared with the initial angiogram (30±9 vs 24±12, p<0.05). In contrast, the CTFC was not evidently improved among patients with suboptimal control. The CTFC at 8 months had thus obviously improved more in patients with optimal, than with suboptimal control (24±12 vs 30±11, p<0.05). Conclusion Optimal control of postprandial hyperglycemia improves epicardial blood flow in both arteries and this beneficial effect might be from improved coronary endothelial function.
- 社団法人日本循環器学会の論文
- 2007-06-20
著者
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SUGI Kaoru
Division of Cardiovascular Medicine, Toho University Ohashi Medical Center
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Sugi Kaoru
Division Of Cardiovascular Medicine Toho University Ohashi Medica Center
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Sugi Kaoru
Division Of Cardiology Toho University
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Nomura Masanori
Department Of Internal Medicine Fujita Health University School Of Medicine
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Nakamura Masato
Department Of Cardiology Ohashi Medical Center Toho University
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Noba Manji
Division Of Cardiology Fujita Health Science Univeristy Second Hospital
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Sugi Kaoru
National Sanatorium Kanagawa Hospital
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Nakamura Masato
Division of Cardiovascular Medicine, Toho University Ohashi Medical Center
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Nakajima Rintaro
Division of Cardiovascular Medicine Toho University Ohashi Medical Center
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Iijima Daisuke
Division of Cardiovascular Medicine, Ohashi Hospital, Toho University School of Medicine
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Nomura Masanori
Division Of Cardiology Fujita Health Science Univeristy Second Hospital
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Nakamura Masato
Division Of Cardiovascular Medicine Toho University Ohashi Hospital
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Nakamura Masato
Division Of Cardiovascular Medicine Ohashi Hospital Toho University School Of Medicine
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Nakamura Masato
Division Of Cardiovascular Medicine Ohashi Medical Center Toho University
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Iijima Daisuke
Division Of Cardiovascular Medicine Ohashi Hospital Toho University School Of Medicine
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Nakajima Rintaro
Division Of Cardiovascular Medicine Ohashi Hospital Toho University School Of Medicine
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Sugi Kaoru
Department Of Cardiology Toho University School Of Medicine Ohashi Hospital
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Nomura Masanori
Department Of Internal Medicine Fujita-gakuen University School Of Medicine Toyoake Aichi 470-11
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Sugi Kaoru
Department Of Cardiology Toho University Ohashi Medical Center
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Nakamura Masato
Division Of Cardiology Third Department Of Medicine Toho University School Of Medicine
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Nakamura Masato
Third Department Of Internal Medicine.toho University
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