Platelet Aggregability Under Shear is Enhanced in Patients With Unstable Angina Pectoris Who Developed Acute Myocardial Infarction

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概要

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• The study investigated whether patients hospitalized for unstable angina pectoris (UAP), who subsequently develop complete coronary thrombosis (acute transmural myocardial infarction (AMI) despite medical treatment, exhibit platelet hyperaggregability in an assay system that does not employ agonist stimulation. The study comprised 89 patients with UAP (Braunwald type B). Unfractionated heparin and nitrate were administered to all patients via continuous intravenous drip together with aspirin taken orally. Citrated platelet-rich plasma (230-250×10^3/μl) was obtained on admission and again, in some patients, following the AMI. Platelet aggregability was measured in an optically modified cone-plate viscometer that enables the detection of platelet aggregation without agonist stimulation. A continuous shear rate of 1, 200/s was employed. Of the 89 patients, 85 were finally stabilized, while 4 developed an AMI accompanied by persistent ST-segment elevation with increased levels of plasma creatine kinase within 3 h after starting the treatment. The extent of platelet aggregation on admission was significantly greater in these 4 patients compared with the 85 who were stabilized (87.8±6.8%, n=4 vs 26.8±9.1%, n=85; mean±SD). These data suggest that platelet hyperaggregability mediated mainly by fibrinogen binding to the activated glycoprotein IIb/IIIa complex occurs before a complete thrombotic occlusion and this evaluation may provide important information before the onset of myocardial infarction.

• 社団法人日本循環器学会の論文
• 2001-03-20

著者

• TAKESHITA Satoshi

  Department of Cardiology, National Cardiovascular Center

• Isshiki Takaaki

  Department of Cardiology, Teikyo University Hospital

• Handa Shunnosuke

  Department Of Cardiology Tokai University School Of Medicine

• Takeshita Satoshi

  Department Of Cardiology

• GOTO Shinya

  Department of Internal Medicine, Tokai University

• Ikeda Yasuo

  Department Of Internal Medicine Keio University

• Sato Tomohide

  Department Of Medicine (cardiology) Teikyo University School Of Medicine

• Sato Tomohide

  Department Of Internal Medicine Teikyo University School Of Medicine

• Isshiki Takaaki

  The Department Of Medicine Teikyo University School Of Medicine

• Ochiai Masahiko

  Department Of Medicine (cardiology) Teikyo University School Of Medicine

• Ochiai Masahiko

  Department Of Chemitsry School Of Science And Engineering Waseda University

• Terakura Moriyuki

  Department of Cardiology, Ageo Central General Hospital

• Terakura Moriyuki

  Division of Cardiology, Teikyo University Hospital

• Eto Koji

  Department Of Medicine (cardiology) Teikyo University School Of Medicine

• Eto Koji

  Department Chemistry & Biochemistry Graduate School Of Engineering Kyushu University

• Goto Shinya

  Department Of Medicine (cardiology) Tokai University School Of Medicine

• ISHIHARA TADAYUKI

  National Higashisaitama Hospital

• Handa Shunnosuke

  Department Of Cardiology School Of Medicine Tokai University

• Handa Shunnosuke

  Department Of Medicine (cardiology) Tokai University School Of Medicine

• Ikeda Yasuo

  Department Of Earth Science Hokkaido University Of Education At Kushiro

• Satoh Takayoshi

  Department Of Cardiology Iwatsuki-minami Hospital

• Takeshita Satoshi

  Division Of Cardiology Department Of Internal Medicine Teikyo University

• Takeshita Satoshi

  Department Of Internal Medicine Teikyo University

• Terakura Moriyuki

  Division Of Cardiology Teikyo University Hospital

• Goto Shinya

  Department Of Cardiology Tokai University School Of Medicine

• Isshiki Takaaki

  Department Of Cardiology

• Terakura Moriyuki

  Department Of Cardiology Ageo Central General Hospital

• Satoh Takayoshi

  Department Of Cardiology

• Ochiai Masahiro

  Second Department Of Medicine Teikyo University School Medicine

• Ikeda Yasuo

  Department Of Medicine (haematology) Keio University School Of Medicine

• Terakura Moriyuki

  Department Of Cardiology Teikyo University School Of Medicine

• Sato Tomohide

  Department Of Cardiology Iwatsuki-minami Hospital

• Ochiai Masahiro

  Department Of Medicine (cardiology) Teikyo University School Of Medicine

• Sato Tomohide

  Department Of Cardiology

• Goto Shinya

  Department Of Cardiology Tokai University

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