MECHANISMS OF TRANSIENT AUGMENTATION OF MYOCARDIAL CONTRACTION AFTER A BRIEF CORONARY OCCLUSION
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概要
- 論文の詳細を見る
The purpose of this study was 1) to clarify whether augmented myocardial contraction after a brief coronary occlusion, i.e. post-ischemic hypercontraction, depends on a transient increase in coronary blood flow or preceding myocardial ischemia, and 2) to identify the role of catecholamines or calcium flux in this phenomenon. Sixteen mongrel dogs were examined in open-chest anesthetized condition. One-minute reperfusion after two-minute total coronary occlusion of the left anterior descending artery resulted in a transient increase in segment shortening. Intracoronary administration of adenosine caused hyperemia without any changes in segment shortening. Two minutes of total coronary occlusion with adenosine caused post-ischemic hypercontraction to the same degree, but without any additional hyperemia. Two minutes of partial occlusion with 75% flow reduction caused less post-ischemic hypercontraction. Post-ischemic hypercontraction did not occur after partial occlusion with 50% flow reduction, irrespective of hyperemia with adenosine during reperfusion. Propranolol or verapamil did not prevent this phenomenon. Thus, post-ischemic hypercontraction is not dependent on the transient increase in coronary blood flow, but is related to the preceding myocardial ischemia. Local release of catecholamines is not likely to be the cause. A calcium antagonist, verapamil, did not modify this phenomenon. The precise mechanism of this phenomenon is still uncertain, although some alterations in cellular hemeostasis, such as ionic changes, are likely to be the cause.
- 社団法人日本循環器学会の論文
- 1992-04-20
著者
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Handa Shunnosuke
Department Of Cardiology Tokai University School Of Medicine
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Yoshikawa Tsutomu
Cardio-pulmonary Division of Keio University School of Medicine
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Akaishi Makoto
Cardiopulmonary Division, Department of Internal Medicine, Keio University School of Medicine
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Yoshikawa Tsutomu
Cardiology Division Department Of Medicine Keio University School Of Medicine
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Akaishi Makoto
Kitasato Institute Hospital
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Nakamura Yoshiro
Geriatrics, School of Medicine, Keio University
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Nakamura Y
Geriatrics School Of Medicine Keio University
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Nishikawa Yasuhiro
Cardiopulmonary Division Dept. Of Med. School Of Med. Keio Univ.
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Nakamura Yoshiro
Department Of Internal Medicine School Of Medicine Keio University
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Handa Shunnosuke
Cardiology Department Of Internal Medicine Tokai University School Of Medicine
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Nakamura Yoshiro
Cardiopulmonary Division, Department of Geriatrics, School of Medicine, Keio University
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IKEDA FUMIHIKO
Cardiopulmonary Division, Department of Medicine, School of Medicine, Keio University
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Nakamura Yoshiro
Dept. Of Intern. Med. Keio Univ. School Of Med.
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Nakamura Yoshiro
Cardio-pulmonary Division Department Of Medicine Keio University School Of Medicine
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Nakamura Yoshiro
Cardiopulmonary Division Department Of Medicine School Of Medicine Keio University
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Nakamura Yoshiro
Department Of Internal Medicine Keio University Hoipital
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HANDA Shunnosuke
Tokai University School of Medicine
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Handa Shunnosuke
Department Of Cardiology School Of Medicine Tokai University
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HANDA Shunnosuke
Health Evaluation and Promotion Center Tokai University Hospital
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Ikeda Fumihiko
Cardiopulmonary Division Department Of Medicine School Of Medicine Keio University
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Handa Shunnosuke
First Department Of Internal Medicine Tokai University
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Nishikawa Yasuhiro
Department Of Internal Medicine School Of Medicine Keio University
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Nakamura Yoshirou
Cardiopulmonary Division School Of Medicine Keio Univ.
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Handa Shunnosuke
Department Of Internal Medicine School Of Medicine Keio University
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Nishikawa Yasuhiro
Cardiopulmonary Division Department Of Medicine Keio University School Of Medicine
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Akaishi Makoto
Cardio-pulmonary Division School Of Medicine Keio University
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Hanada Shunnosuke
Division Of Cardiology Tokai University School Of Medicine
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Ikeda Fumihiko
Cardiopulmonary Division Department Of Medicine Keio University
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Akaishi Makoto
Cardio-pulmonary Division Dept. Of Internal Medicine School Of Medicine Keio University
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Nakamura Yoshiro
Cardiopulmonary Division. Department Of Internal Medicine Keio University
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Handa Shunnosnke
Cardiopulmonary Division. Department Of Internal Medicine Keio University
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Handa Shunnosuke
Department Of Medicine Tokai University Hospital
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Nakamura Yoshirou
Cardiopulmonary Division. Department Of Internal Medicine Keio University
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Handa Shunnosuke
Department Of Internal Medicine School Of Medicine Tokai University
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Handa Shunnosuke
Cardio-pulmonary Division Dept. Of Internal Medicine School Of Medicine Keio University
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