Oral Sildenafil Improves Primary Pulmonary Hypertension Refractory to Epoprostenol

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Background Epoprostenol (prostaglandin I_2) has become recognized as a therapeutic breakthrough that can improve hemodynamics and survival in patients with primary pulmonary hypertension (PPH). However, a significant number of patients have PPH that is refractory to epoprostenol, and lung transplantation has been the only remaining treatment option. Methods and Results The study subjects included 20 consecutive patients with PPH (mean pulmonary arterial pressure : 65±15 mmHg) who had received epoprostenol for more than 12 months. The patients were divided into 2 groups ; responders and non-responders. In the non-responders, New York Heart Association (NYHA) functional class did not improve and mean right atrial pressure (mRA) increased to 8mmHg or more, and additional sildenafil, a phosphodiesterase-5 inhibitor, was started. Six patients were included in the non-responders, whose mRA was 9±5mmHg before and significantly increased to 13±3mmHg after epoprostenol administration (p<0.05). One patient died and the other 5 patients received oral sildenafil. The mRA of 12±4mmHg (value before sildenafil) improved to 8±5mmHg after sildenafil administration. Three patients were classified in the NYHA functional class 4 and improved to class 3, and 2 patients were in class 3 and remained in the same class after the addition of sildenafil. Conclusions In patients with severe PPH refractory to epoprostenol treatment, additional oral sildenafil can improve pulmonary hemodynamics and symptoms. The combination therapy of epoprostenol and sildenafil is a new medical treatment to attempt before progressing to lung transplantation for patients with PPH refractory to epoprostenol.
社団法人日本循環器学会の論文
2005-03-20

Oral Sildenafil Improves Primary Pulmonary Hypertension Refractory to Epoprostenol

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