Patients With Peripheral Artery Disease Who Complete 12-Week Supervised Exercise Training Program Show Reduced Cardiovascular Mortality and Morbidity(Vascular Medicine)
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概要
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Background Exercise training improves walking ability in patients with peripheral arterial disease (PAD), but whether exercise training improves the long-term outcome of these patients remains unknown. Methods and Results Participants were 118 PAD patients who were enrolled in a 12-week supervised exercise program. The long-term outcomes of 64 patients who completed the training were compared with the outcomes of 54 patients who did not. The primary endpoint was cardiovascular mortality, and the secondary endpoint was cardiovascular morbidity. Mean follow-up was 5.7±3.9 years. The cardiovascular death-free rate was higher in patients who completed the training program than in those who did not (P=0.022). Multivariate analysis showed independent predictors of cardiovascular death were age over 70years, diabetes mellitus, maximum walking distance, history of coronary revascularization, and completion of training program. The cardiovascular event-free rate was also higher in patients who completed the training program (P=0.048). Conclusions Supervised exercise training improved cardiovascular mortality and morbidity in patients with PAD, which suggests that exercise training should be considered as a secondary prevention strategy for these patients.
- 2008-12-20
著者
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Hashimoto Hideki
Department of Health Economics and Epidemiology Research, School of Public Health, The University of
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YOKOYAMA Naoyuki
Department of Cardiology, National Cardiovascular Center
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TAKESHITA Satoshi
Department of Cardiology, National Cardiovascular Center
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Takeshita Satoshi
Department Of Cardiology
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Akutsu Koichi
Department of Cardiology, National Cardiovascular Center
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Akutsu Koichi
Department Of Cardiovascular Medicine National Cardiovascular Center
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Yamada Naoaki
Department Of Cardiology National Cardiovascular Center
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Tamori Yuiichi
Department of Cardiovascular medicine, National Cardiovascular Center
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Sakamoto Shingo
Department of Caridovascular Medicine, National Cardiovascular Center
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Sakamoto Shingo
Department Of Cardiovascular Medicine National Cardiovascular Center
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Yokoyama Naoyuki
Department Of Cardiology National Cardiovascular Center
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Tamori Yuiichi
Department Of Cardiovascular Medicine National Cardiovascular Center
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Tamori Yuiichi
Department Of Cardiology International Medical Center Of Japan
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Takeshita Satoshi
Department Of Cardiovascular Medicine Department Of Cardiovascular Surgery
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Yokoyama Naoyuki
Department Of Cardiovascular Medicine National Cardiovascular Center
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Yokoyama Naoyuki
Department Of Cardiology National Cadiovascular Center
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Takeshita Satoshi
National Cardiovascular Center Research Institute
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Hashimoto Hideki
Department Of Health Economics And Epidemiology Research (h. Hashimoto) School Of Public Health Univ
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Hashimoto Hideki
Department Of Health Management And Policy Graduate School Of Medicine University Of Tokyo
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Hashimoto Hideki
Department Of Applied Mathematics And Physics Graduate School Of Informatics Kyoto University
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