Association Between Hepatitis C Virus Core Protein and Carotid Atherosclerosis
スポンサーリンク
概要
- 論文の詳細を見る
A link between certain infectious microorganisms and an increased risk of atherosclerotic disease has been suggested. By analyzing the data of subjects who had undergone general health-screening tests, a possible association between carotid atherosclerosis and seropositivity of antibody against hepatitis C virus (HCV) has been previously reported. In the present study, a possible link between carotid atherosclerosis and HCV core protein positivity was assessed, because it is postulated to be a better marker of viremia and thus persistent infection, Of the 1992 enrolled subjects, 496 (25%) had carotid artery plaque, and 25 (1.3%) were positive for HCV core protein. Carotid artery plaque was positive in 480/1967 (24%) and 16/25 (64%) of the core protein-negative and core protein-positive subjects, respectively (p<0.0001 by χ^2 test). Serum concentrations of transaminases were higher in core protein-positive subjects, but albumin concentrations were not significantly different between the 2 groups. Multivariate logistic regression analysis showed that HCV core protein positivity is an independent predictor of carotid plaque with an odds ratio of 5.61 (95% confidence interval 2.06-15.26, p<0.001). These data further support the possible link between persistent HCV infection and carotid atherosclerosis in the subjects without severe liver dysfunction.
- 社団法人日本循環器学会の論文
- 2002-12-20
著者
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NAGAI Ryozo
Department of Cardiovascular Medicine, University of Tokyo
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Hashimoto Hideki
Department of Health Economics and Epidemiology Research, School of Public Health, The University of
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ISHIZAKA Yuko
Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital
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YAMAKADO Minoru
Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital
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高橋 英孝
野村病院予防医学センター
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Nagai Ryozo
武蔵野赤十字病院
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ISHIZAKA Nobukazu
Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine
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Ishizaka Yuko
Center For Multiphasic Health Testing And Services Mitsui Memorial Hospital
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高橋 英孝
東海大学 医学部基盤診療学系健康管理学
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Yamakado Minoru
Center For Multiphasic Health Testing And Services Mitsui Memorial Hospital
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Tooda Ei-ichi
Center For Multiphasic Health Testing And Services Mitsui Memorial Hospital
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Takahashi Eiko
Center For Multiphasic Health Testing And Services Mitsui Memorial Hospital
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Takahashi Eiko
Department Of Public Health Showa University School Of Medicine
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Takahashi Eiko
Department Of Public Health St. Marianna University School Of Medicine
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Takahashi Eiko
Department Of Hygiene And Preventive Medicine Showa University School Of Medicine
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Ishizaka Nobukazu
Department Of Cardiovascular Medicine University Of Tokyo Graduate School Of Medical Sciences
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Unuma Tadao
Center For Multiphasic Health Testing And Services Mitsui Memorial Hospital
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Nagai Ryouzou
The Department Of Cardiovascular Diseases Graduate School Of Medicine University Of Tokyo
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Yamakado Minoru
Mitsui Memorial Hospital
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Ishizaka Nobukazu
Department Of Cardiovascular Medicine University Of Tokyo
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Nagai Ryozo
Department Of Cardiology Kitano Hospital Medical Research Institute
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Hashimoto Hideki
Department Of Health Economics And Epidemiology Research (h. Hashimoto) School Of Public Health Univ
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Nagai Ryozo
Department Cardiovascular Medicine The University Of Tokyo Hospital
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Hashimoto Hideki
Department Of Applied Mathematics And Physics Graduate School Of Informatics Kyoto University
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Ishizaka Nobukazu
Department Of Cardiology Osaka Medical College
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