Effect of Apolipoprotein E Genotype on Association of Menopausal Status with Lipid Level in Japanese Women

概要

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Serum lipid level increases during hormonal transition before and after menopause. In Caucasians, changes in lipid level after menopause across apolipoprotein E (apo E) genotypes were studied. We investigated 159 Japanese healthy female workers (age range, 35-63). The apo E genotypes were determined by the polymerase chain reaction single-strand conformation polymorphisms method for the entire apo E-coding region. The low-density lipoprotein cholesterol (LDL-cholesterol) level significantly varied according to the apo E genotype, but not according to the menopausal status after adjusting for age and body mass index (p<0.001). The effect of menopause on LDL-cholesterol level significantly varied depending on the apo E genotype (p<0.05). Apo E2 [APOE, R158C] carriers in the senium period had a lower LDL-cholesterol level than those in the fertile period (81.5±12.0 mg/dl vs. 122.3±12.9 mg/dl). In contrast, apo E3 homozygotes in the senium period showed a higher LDL-cholesterol level than those in the fertile period (140.9±7.0 mg/dl vs. 134.1±6.1 mg/dl). The LDL-cholesterol levels of apo E4 [APOE, C112R] carriers were the similar for the two periods. These results indicate that the serum lipid control in perimenopausal women should be customized according to the apo E genotype for the promotion of women's health in Japan.
社団法人日本薬学会の論文
2006-10-01