Coronary Collateral Circulation as an Important Factor to Modify the Ischemic Injury of the Myocardium in Coronary Ligated Dogs

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概要

• 論文の詳細を見る

• Effect of coronary ligation on epicardial and intramyocardial ST-segment voltage was investigated in 121 dogs. After ligation of the anterior descending coronary artery, marked ST-elevation, more than 2mV, was detected in 102 dogs (Group-I) in epicardial lead of the area which was nourished by the ligated coronary artery. In 7 dogs (Group-II), coronary ligation produced negligible changes in ST-segment voltage in epicardial lead, while significant ST-elevation was observed in the leads of middle and inner layers of the myocardium. Systemic hemodynamic parameters showed no statistically significant difference between the 2 groups. Coronary collateral indices, however, revealed the significant difference between them. Systolic peripheral coronary pressure was 29.3±3.1mmHg in Group-I and 59.2±10.6mmHg in Group-II (p<0.05). Retrograde flow was also greater in Group-II (14.8±4.4ml/min) than in Group-I (1.3±0.5ml/min) (p<0.01). Diversion of retrograde flow produced a marked ST-elevation in Group-II. Restoration of retrograde flow to the myocardium immediately decreased the ST-segment voltage. These results suggest that spontaneously developed collaterals have an important function for the prevention of the occurrence of ischemic injury after coronary ligation in dogs.

• International Heart Journal刊行会の論文

著者

• Yokoyama Mitsuhiro

  First Department Of Internal Medicine Kobe University School Of Medicine

• Fukuzaki Hisashi

  First Department of Internal Medicine Kobe University School of Medicine

• Fukuzaki Hisashi

  First Department Of Internal Medicine Kobe University

• Mizutani Tetsuo

  Department Of Internal Medicine Kobe National Hospital

• Yokoyama Mitsuhiro

  First Department Of Internal Medicine Kobe University

• Mizutani Tetsuro

  Dept. Of Intern. Med. Div. I Kobe Univ. School Of Med.

• Mizutani Tetsuo

  The First Department Of Internal Medicine. Faculity Of Medicine. Kobe University

• MAEKAWA Kishio

  First Department of Internal Medicine, Kobe University Hospital

• KATADA Yutaka

  First Department of Internal Medicine, Kobe University Hospital

• MIZUTANI Tetsuo

  First Department of Internal Medicine, Kobe University Hospital

• Yokoyama Mitsuhiro

  First Department Of Internal Medicine

• YOKOYAMA Mitsuhiro

  First Department of Internal Medicine, School of Medicine, Kobe University

• MIZUTANI Tetsuo

  First Department of Internal Medicine, School of Medicine, Kobe University

• FUKUZAKI Hisashi

  First Department of Internal Medicine, School of Medicine, Kobe University

• KATADA Yutaka

  First Department of Internal Medicine, School of Medicine, Kobe University

• MAEKAWA Kishio

  First Department of Internal Medicine, School of Medicine, Kobe University

• MIZUTANI Tetsuo

  First Department of Internal Medicine, Kobe Medical College

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