Hemodynamic Effects of Digoxin on Congestive Heart Failure : PANEL DISCUSSION ON OPINIONS OF CARDIOTONIC DRUGS : 49th Annual Scientific Session of the Japanese Circulation Society

概要

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To assess the hemodynamic effects of digoxin (0.01 mg/kg) on congestive heart failure, we evaluated 19 patients with decreased contraction force of left ventricle (old myocardial infarction n=9, and dilated cardiomyopathy n=10, group 1) and 8 patients with mechanical impaired left ventricular filling (mitral stenosis n=8, group 2). In groups 1 and 2, heart rate and pulmonary capillary pressure significantly decreased (p < 0.05). In group 1. stroke volume increased, but not significantly. In group 2, stroke volume increased significantly (p < 0.05). There were no significant changes in blood pressure and systemic vascular resistance in either group. We divided group 1 into two groups (group 1A : cardiac index increased more than 15%, group 1B : cardiac index increased less than 15%). In group 1A, cardiac index and % fractional shortening before digoxin administration were lower than in group 1B (1.97 + 0.27 vs 2.80 + 0.481/min/m^2, p < 0.001, and 10.9 + 8.0 vs. 19.5 + 11.9%, p < 0.05, respectively). These data suggested that digoxin exerted a positive inotropic effect with decreased pulmonary capillary pressure, but cardiac index did not always increase in congestive heart failure.
社団法人日本循環器学会の論文
1986-07-20