Studies on the Preventive Method of Lowered Ventricular Fibrillation Threshold during Experimental Acute Myocardial Infarction : A Comparison between Disopyramide Phosphate and Lidocaine

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概要

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• This study was performed to investigate the prophylactic effect of disopyramide phosphate on ventricular fibrillation in acute myocardial infarction. Lidocaine and disopyramide phosphate were compared in terms of their effects on the lowered ventricular fibrillation threshold in experimental myocardial infarction produced by coronary ligation in dogs. The following results were obtained:1) The effect of lidocaine i.v.+infusion appeared promptly and the ventricular fibrillation threshold exceeded control levels from 45min onwards (p<0.01).2) The i.m. injection of lidocaine was effective in a dose of 10mg/Kg. The minimally effective blood level was 1.7mcg/ml.3) Disopyramide phosphate 5mg/Kg i.v. produced a tendency towards recovery from 15min onwards. After 30min, the ventricular fibrillation threshold was significantly higher than control (p<0.01).4) Disopyramide phosphate 5mg/Kg i.m. was initially effective after 45min. The effect was significant from 1 hour and 30min onwards, compared with control (p<0.01). The minimally effective blood level was 2.4mcg/ml.5) Disopyramide phosphate 2mg/Kg i.m. produced a tendency towards recovery but the difference from the control was not significant.6) In equivalent i.m. doses, disopyramide phosphate tended to be more potent than lidocaine in increasing the ventricular fibrillation threshold.7) In the aforementioned doses, disopyramide phosphate did not cause any marked changes in PQ interval or QT time in ECG.These results suggest that the intramuscular injection of disopyramide phosphate is a hopeful clinical treatment to prevent ventricular fibrillation in the very early stages of acute myocardial infarction.

• International Heart Journal刊行会の論文

著者

• Fukuzaki Hisashi

  First Department of Internal Medicine Kobe University School of Medicine

• Fukuzaki Hisashi

  First Department Of Internal Medicine Kobe University

• Hori Yasuro

  Department Of Internal Medicine Div. I Kobe University School Of Medicine

• HORI Yasuro

  First Department of Internal Medicine, Kobe University School of Medicine

• OKAMOTO Ryozo

  First Department of Internal Medicine, Kobe University School of Medicine

• HATANI Makoto

  First Department of Internal Medicine, Kobe University School of Medicine

• IMAI Naoaki

  First Department of Internal Medicine, Kobe University School of Medicine

• TOH Hideo

  First Department of Internal Medicine, Kobe University School of Medicine

• TAKANO Shinji

  First Department of Internal Medicine, Kobe University School of Medicine

• NADAI Taneichi

  Department of Pharmacology, Jyosai University

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