Y-8894の薬理学的研究-3-ラット内包破壊誘発皮質異常脳波に及ぼす影響

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The effect of Y-8894 on the abnormal electrocorticogram (ECoG) of alcuronium-immobilized rats, induced by destruction of the internal capsule with heat, was compared with that produced by imipramine, amantadine and Ca-hopantenate. ECoG power in the delta+ theta (1 ?? 7 Hz), alpha (7.5 ?? 12.5 Hz) and beta (13 ?? 30 Hz) bands was used as an index. Delta+theta power increased following destruction of the internal capsule with heat. The increased delta+theta power (abnormal ECoG) lasted for 60 min following the injection of saline at 60°C for 3 min. Y-8894 (0.1 ?? 1 mg/kg, i.v.) apparently improved the abnormal ECoG dose-dependently by significantly reducing the increased delta+theta power. Similar results were obtained with amantadine (10 mg/kg, i.v.), but its potency was weaker than that of Y-8894. Imipramine (1 mg/kg, i.v.) and Ca-hopantenate (30 mg/kg, i.v.), however, both failed to modify the abnormal ECoG. All drugs, except Ca-hopantenate, decreased the magnitudes of the alpha and beta bands. The above results suggest that Y-8894 may be effective in ameliorating cerebral dysfunction induced experimentally by the lesion of the internal capsule.
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