キノホルム関連化合物の毒性に関する病理組織学的研究

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In our experiment a histopathological study of subacute toxicity of chinoform (CF), quinoline (QL), oxine (OX), chinoform iron chelate (C-C) and sulfate conjugation of chinoform (C-S) was carried out in the rat. Results are as follows : Toxic symptoms were observed in the CF, OX and QL groups, however the C-C and C-S groups, revealed no effects of toxicity. Histopathological examination demonstrated degeneration of the cerebral cortex cervical and lumbar neurons, and in particular the sciatic nerve, peroneal and tibial nerves in the CF treated rats. Specifically, axonal disruption, fragmentation and vacuolization of the myelin sheath were observed. QL and OX caused no degeneration in the cerebrum and cervical neurons. Slight degeneration was observed in the lower lumbar cord and the sciatic nerve. C-C had no effect on the nervous system but a slight degeneration was observed in the viscera.
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