循環器系に対するアドレナリン誘導体の作用〔英文〕

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The effect of adrenaline derivatives, such as ethyl-adrianol, butyl-sympatol and meta-proterenol on the circulatory system were investigated, and it was found that the pressor action mechanism of ethyl-adrianol appears to stimulate the adrenals to release noradrenaline-like substances as well as promoting contractive action on peripheral blood vessels. Butyl-sympatol and meta-proterenol show a depressor action as a result of the peripheral vasodilating action caused by stimulation of adrenergic β-receptor. Ethyl-adrianol, butyl-sympatol and meta-proterenol activate cardiac performance. Particularly evident was the increase of cardiac contractile force. Ethyl-adrianol had a contractive effect on peripheral blood vessels, while butyl-sympatol and meta-proterenol had dilating effects. A contrastive effect on isolated seminal vesicles of rats was also observed with this adrenaline derivatives.<BR>Adrenergic β-receptor stimulants are utilized bronchodilating agents. Certain isoproterenol derivatives cause adverse side effects such as substernal constriction, angina pectorislike pain and hypotensive effects. The authors have reported that adrenaline derivatives cause a dilating effect on the bronchial muscles and in order of potency, it was found that isoproterenol, meta-proterenol, adrenaline, ethyl-adrianol, noradrenaline and butyl-sympatol had this action.<BR>The objective of the studay was to investigate the effect of adrenaline derivatives, such as ethyl-adrianol, butyl-sympatol and meta-proterenol on the circulatory system, the results of which are in compared with those of adrenaline and noradrenaline.
学校法人昭和大学・昭和医学会の論文

循環器系に対するアドレナリン誘導体の作用〔英文〕

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