摘出モルモット気管筋に対する2,3アドレナリン誘導体の作用

概要

論文の詳細を見る
The effects of the adrenaline derivatives, Meta-proterenol (M-P), Ethyl-adrianol (E-A) and Butylsympatol (B-S) on isolated tracheal muscle from guinea pigs were compared with those of isoproterenol, adrenaline and noradrenaline. 1) The decreasing order of potency of dilating action on isolated trachea was isoproterenol, M-P, adrenaline, E-A, noradrenaline and B-S. 2) Antagonism by the adrenaline derivatives against the tracheal constrictions induced by histamine, ACh, 5-HT and barium chloride was observed. These constricting agents were added to the bath fluid at concentrations to evoke 60% of control responses. The order of antagonistic activity of the adrenaline derivatives corresponded to the order obtained in the preceding section 1). 3) In the presence of propranolol, these adrenaline derivatives caused constriction of the tracheal muscle, which disappeared by treatment with ergotamine. In conclusion, these results indicate that the adrenaline derivatives have stimulating actions on both the adrenergic β-receptors and, to a much lesser extent, on α-receptors.
社団法人日本薬理学会の論文