TOXICOLOGICAL STUDIES OF ANEMIA BY P-METHYLPHENYLHYDRAZINE : DRUG INDUCED PHAGOCYTOSIS OF P-METHYLPHENYLHYDRAZINE INJURED ERYTHROCYTES BY MACROPHAGES
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Hemolytic anemia was induced in dogs with repeated intravenous injections of p-methylphenylhydrazine (MPH), phenylhydrazine (PH) or nitrite for five days (10 mg/kg day each). Both erythrocyte number and hemoglobin concentration were decreased more by MPH than by PH or nitrite. Reticulocytes were also increased more by MPH than by PH or nitrite. Phagocytosis of MPH-injured erythrocytes by macrophages was observed in vitro. Erythrocyte number was decreased about 30 % by MPH upon repeated intraperitoneal administration of anti-macrophage serum compared to about 45 % effect without anti-macrophage serum. Those results show that MPH-induced hemolytic anemia is caused by macrbphagic phagocytosis of MPH-injured erythrocytes.
- 1977-07-15
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関連論文
- TOXICOLOGICAL STUDIES OF ANEMIA BY P-METHYLPHENYLHYDRAZINE : DRUG INDUCED PHAGOCYTOSIS OF P-METHYLPHENYLHYDRAZINE INJURED ERYTHROCYTES BY MACROPHAGES
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