Amantadineのラット脳serotonin代謝におよぼす効果について

概要

論文の詳細を見る
Several pharmacological and biochemical studies have indicated the interaction of amantadine (Symmetrel), which has proven clinically effective for Parkinsonism, via the central catecholaminergic mechanism. In this study, effect of amantadine on serotonin metabolism was inv. _??_igated in the rat brain. Male Wistar rats weighing 100_??_200g were given amantadine i. p. or together as a mixture with the diet. 5HT content (Bogdanski et al.), 5HIAA content (Giacalone and Valzelli), aromatic amino acid decarboxylase (AADC) activity (Lovenberg et al.) and MAO activity (Wurtman and Axelrod) were estimated in the brain and the other tissues. Significant changes were not found on the entire brain serotonin level or the AADC activity with amantadine treatment (50 and 100mg, i. p.), while one hr following amantadine 100mg/kg, i. p. injection, 5HIAA content and MAO activity were slightly reduced. In 0.01% and 0.05% amantadine fed rats, brain serotonin level was found to be slightly increased. Four days after 0.05% amantadine feeding, MAO activity was significantly reduced while 5HT levels were significantly elevated. Nine days after amantadine, 5HT levels recovered to the initial level. Brain MAO activity was also inhibited in vitro by adding amantadine to incubation medium. MAO inhibition (nialamide 100mg/kg, i. p.) induced 5HT accumulation in the brain was enhanced by amantadine treatment. These findings indicate that amantadine affects not only the central adrenergic but also the serotonergic nervous system.
社団法人日本薬理学会の論文

Amantadineのラット脳serotonin代謝におよぼす効果について

スポンサーリンク

概要

著者

関連論文

スポンサーリンク