嫌気性発酵由来E. coliのコバルh塩添加によるVitamin B12生産の増加

概要

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Vitamin B12 producing E. coli was isolated by anaerobic fermentation. By means of biological quantification with E. coli mutant strain 215, the bacterial produc-tion of vitamin B12 in the presence of cobalt chloride (CoC12•2H2O) or cobalt sulfate (CoSO4•7H2O) was studied in the E. coli cells harvested from anaerobic fermentation, using cultured cells (dry and wet) and concentrated culture.A significant increase was found in vitamin B12 content between the dry cells treated with cobalt chloride (8mg/l) or cobalt sulfate (10mg/l) and the control cells not treated with cobalt salts (p<0.01). The production of vitamin B12 was increased by 4.5-6.2 times via the addition of cobalt salts, compared to that without the addition of these agents.
社団法人日本畜産学会の論文